Age and the effect of exercise, nutrition and cognitive training on oxidative stress - the Vienna Active Aging Study (VAAS), a randomized controlled trial.

Age and the effect of exercise, nutrition and cognitive training on oxidative stress - the Vienna Active Aging Study (VAAS), a randomized controlled trial. Free Radic Biol Med. 2018 Apr 23;: Authors: Franzke B, Schober-Halper B, Hofmann M, Oesen S, Tosevska A, Henriksen T, Poulsen HE, Strasser EM, Wessner B, Wagner KH Abstract The purpose of this study was to investigated the effect of age - over or under life-expectancy (LE) - on six months resistance training alone or combined with a nutritional supplement, and cognitive training by analyzing markers for oxidative stress and antioxidant defense in institutionalized elderly, living in Vienna. Three groups (n=117, age=83.1±6.1 years) - resistance training (RT), RT combined with protein and vitamin supplementation (RTS) or cognitive training (CT) - performed two guided training sessions per week for six months. Oxidative stress, antioxidant defense and DNA strand breaks were analyzed and transformed into an "antioxidant factor" to compare the total effect of the intervention. Physical fitness was assessed by the 6-minutes-walking, the chair-rise and the handgrip strength tests. We observed significant negative baseline correlations between 8-oxo-7.8-dihydroguanosine and handgrip strength (r = -0.350, p = 0.001), and between high sensitive troponin-T and the 6-minutes-walking test (r = -0.210, p = 0.035). RT and RTS groups, showed significant improvements in physical performance. Over...
Source: Free Radical Biology and Medicine - Category: Biology Authors: Tags: Free Radic Biol Med Source Type: research