874 Elevated expression of osteopontin splice variants in nonmelanoma skin cancer compared to normal skin and adult keratinocytes

Elevated expression of osteopontin (OPN), a matricellular, adhesive glycoprotein, is associated with numerous cancer types. We have reported that ultraviolet B (UVB)-induced OPN is a critical driver for cutaneous squamous cell carcinoma (cSCC) development in the photocarcinogenesis model. In human skin cancer, UVB exposure is the major risk factor on the development of nonmelanoma skin cancer. Immunohistochemical analyses indicated that OPN protein is markedly increased in actinic keratoses, cSCC, and differentiated basal cell carcinoma (BCC), but not in solid basal cell epitheliomas when compared with no sun-exposed skin.
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Growth Factors, Cell Adhesion and Matrix Biology Source Type: research