Editorial commentary: Beta blockers and the inertia of evidence-based medicine

One of the key limitations of evidence-based medicine is that most evidence becomes outdated. Secular changes in the epidemiology, diagnosis, and treatment of disease invariably erode the continued relevance of even the most well-conducted trials. As newer therapies are gradually stacked on the backs of older ones, the latter ’s effect sizes should tend to diminish or even disappear. Truly evidence-based medicine therefore requires a continuous reassessment of past successes, ideally through new randomized clinical trials in contemporary cohorts [1].
Source: Trends in Cardiovascular Medicine - Category: Cardiology Authors: Source Type: research