Sigmoidoscopy Curbs Colon Cancer Risk and Death for Men, Not Women Sigmoidoscopy Curbs Colon Cancer Risk and Death for Men, Not Women
Sigmoidoscopy screening in Norway reduced colorectal cancer (CRC) incidence and death in men but had little effect in women, researchers say.Reuters Health Information
ConclusionsScreening colonoscopy was associated with greater reductions in CRC mortality than screening sigmoidoscopy, and with a greater reduction in the distal than the proximal colon. These results provide additional information on the relative benefits of screening for CRC with sigmoidoscopy and colonoscopy.
Condition: Colorectal Cancer Interventions: Other: Right time eating; Other: Delayed time eating; Procedure: Sigmoidoscopy; Procedure: Optional 24h circadian assessment in the Biological Rhythms lab; Other: Alcohol Sponsor: Rush University Medical Center Recruiting
We describe the epidemiologic shifts of CRC incidence and mortality across age groups as well as the differences in clinicopathologic, molecular, treatment, and survival characteristics between young and older patients. Novel studies of the microbiome may elucidate bacterial causes of CRC carcinogenesis in younger individuals. Moving up the colonoscopy screening to age 45 in normal-risk individuals should prove beneficial in detecting more patients with early-onset CRC.SummaryWe favor the development of risk-adaptive screening decision algorithms and flexible sigmoidoscopy screening at age 40 given the predilection for lef...
In this issue ofJAMA Internal Medicine, Pierre-Victor and Pinsky use data from the Prostate, Lung, Colorectal and Ovarian (PLCO) Cancer Screening trial to demonstrate an association between lack of adherence to cancer screening and increased mortality from causes not related to the screening. Participants in the PLCO Cancer Screening trial were 55 to 74 years of age and generally healthy. At trial entry, participants of both sexes in the screening arm were asked to undergo chest radiographs for lung cancer and flexible sigmoidoscopy for colon cancer, men were asked to undergo prostate-specific antigen tests and digital rec...
Whole-colon investigation vs. flexible sigmoidoscopy for suspected colorectal cancer based on presenting symptoms and signs: a multicentre cohort study, Published online: 19 December 2018; doi:10.1038/s41416-018-0335-zWhole-colon investigation vs. flexible sigmoidoscopy for suspected colorectal cancer based on presenting symptoms and signs: a multicentre cohort study
Background: The frequency of preventive health practices (PHP), including age-appropriate screening for malignancies and immunizations, and compliance with PHP guidelines in lymphoma survivors is not known. We hypothesized that lymphoma survivors are more compliant with PHP than the general population but PHP rates may differ based on patient, disease and treatment characteristics.Methods: We identified eligible lymphoma patients from the SPORE Molecular Epidemiology Resource (MER) cohort, in which they were prospectively enrolled within 50 years and compliant if they had fecal occult blood test
CONCLUSION: The combination of an increasing incidence of colorectal cancer in those under 50 years of age and the predominance of left-sided cancer suggests that screening by flexible sigmoidoscopy starting at age 40 in average-risk individuals may prevent cancer by finding asymptomatic lesions. See Video Abstract at http://links.lww.com/DCR/A579.
Endosc Int Open 2018; 06: E872-E877 DOI: 10.1055/a-0591-9308 Background and study aims UK Bowel Cancer Screening flexible sigmoidoscopy (BowelScope) currently offers patients aged 55 a one-off flexible sigmoidoscopy for adenoma clearance to decrease colorectal cancer incidence by interrupting the adenoma-carcinoma sequence. Recent evidence has shown maximum benefit in increasing adenoma detection rate (ADR) using the Endocuff Vision device in the left side of the colon and in screening patients. Currently, ADR is low and shows unacceptable variation in BowelScope. ADR is a quality indicator in screening sigmoidosco...
Fecal immunochemical test (FIT) and sigmoidoscopy have been used for colorectal cancer (CRC) screening worldwide. However, the limitations are poorer test sensitivity for advanced neoplasia (AN) and isolated detection in distal colon, respectively. Through this prospective multicenter trial, we compared the detection rate of AN between FIT plus sigmoidoscopy (SIG) based colonoscopy (FITS group) and colonoscopy (COLO group).
Flexible sigmoidoscopy has become an important tool for colorectal cancer screening but unfortunately lacks visualization of more proximal colonic lesions. Colorectal lesions found during flexible sigmoidoscopy may warrant further proximal colonic lesion investigation. There however is limited research on the frequency of right-sided precancerous polyps in the absence of polyps in the left colon.