Cardioprotection by ischemic postconditioning and cyclic guanosine monophosphate-elevating agents involves cardiomyocyte nitric oxide-sensitive guanylyl cyclase

ConclusionsThese findings demonstrate an important role of CM NO-GC for the cardioprotective signalling following AMIin vivo. CM NO-GC function is essential for the beneficial effects on infarct size elicited by iPost and pharmacological elevation of cGMP; however, lack of CM NO-GC does not seem to disrupt the cardioprotection mediated by the BK opener NS11021.

https://academic.oup.com/cardiovascres/article/114/6/822/4846911?rss=1

Source: Cardiovascular Research - February 9, 2018 Category: Cardiology Source Type: research