Systemically transplanted human gingiva-derived mesenchymal stem cells contributing to bone tissue regeneration.

In this study, we transplanted human GMSCs into C57BL/6J mice with defects in mandibular bone via the tail vein to explore the capacity of transplanted GMSCs to promote bone regeneration. Results showed that the transplanted GMSCs were detected in the bone defects and employed in new bone formation. And the newly formed bone area in mice with GMSCs transplantation was significantly higher than that in control mice. Our findings indicate that systemically transplanted GMSCs can not only home to the mandibular defect but also promote bone regeneration. PMID: 25197363 [PubMed - in process]

http://www.ncbi.nlm.nih.gov/pubmed/25197363?dopt=Abstract

Source: International Journal of Clinical and Experimental Pathology - September 15, 2014 Category: Pathology Authors: Xu QC, Wang ZG, Ji QX, Yu XB, Xu XY, Yuan CQ, Deng J, Yang PS Tags: Int J Clin Exp Pathol Source Type: research