328 50% wound healing correlates with RDEB patient reported outcomes in pain, itch and skin durability

We report on wound healing and high correlation to patient reported outcomes in our Phase I/IIA clinical trial of ex vivo C7 gene therapy (LEAES grafts, EB-101) for treatment of chronic wounds in severe RDEB (N=7 adults, 36 wounds assessed). There is limited information on measuring dynamic wounds in RDEB and the amount of wound healing that is clinically meaningful in patient reported outcomes. We compared 2 methods to calculate wound surface area: quantitative 3D imaging with high-resolution Canfield camera (Vectra H1) vs.
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Clinical Research: Epidemiology of Skin Diseases Source Type: research