Brain Iron Distribution after Multiple Doses of Ultra-small Superparamagnetic Iron Oxide Particles in Rats.

Brain Iron Distribution after Multiple Doses of Ultra-small Superparamagnetic Iron Oxide Particles in Rats.
Comp Med. 2019 Mar 01;68(2):139-147
Authors: Gorman AW, Deh KM, Schwiedrzik CM, White JR, Groman EV, Fisher CA, Gillen KM, Spincemaille P, Rasmussen S, Prince MR, Voss HU, Freiwald WA, Wang Y
Abstract
The purpose of this study is to determine the effects of high cumulative doses of ultra-small paramagnetic iron oxide (USPIO) used in neuroimaging studies. We intravenously administered 8 mg/kg of 2 USPIO compounds daily for 4 wk to male Sprague-Dawley rats (Crl:SD). Multiecho gradient-echo MRI, serum iron levels, and histology were performed at the end of dosing and after a 7-d washout period. R2* maps and quantitative susceptibility maps (QSM) were generated from multiecho gradient-echo data. R2* maps and QSM showed iron accumulation in brain ventricles on MR images acquired at the 4- and 5-wk time points. Estimates from QSM data showed ventricular iron concentration was equal to or higher than serum iron concentration. Histologic analysis revealed choroid plexus hemosiderosis and midbrain vacuolation, without iron deposition in brain parenchyma. Serum iron levels increased with administration of both compounds, and a 7-d washout period effectively reduced serum iron levels of one but not both of the compounds. High cumulative doses from multiple, frequent administrations of USPIO can lead to iron deposition in brain ventricles,...

Source: Comparative Medicine - April 12, 2018 Category: Zoology Authors: Gorman AW, Deh KM, Schwiedrzik CM, White JR, Groman EV, Fisher CA, Gillen KM, Spincemaille P, Rasmussen S, Prince MR, Voss HU, Freiwald WA, Wang Y Tags: Comp Med Source Type: research