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Etiology, ethics, and outcomes of chronic kidney disease in neonates.

CONCLUSION: Congenital anomalies of the kidneys and urinary tract is the most common etiology in neonates with CKD. Chronic kidney disease in neonates is associated with high morbidity and mortality rates. PMID: 29619487 [PubMed - in process]
Source: Saudi Medical Journal - Category: Middle East Health Tags: Saudi Med J Source Type: research

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Publication date: Available online 13 March 2018 Source:American Journal of Kidney Diseases Author(s): Yoshio N. Hall There is ongoing recognition that a wide array of social, economic, and environmental factors influence individuals’ opportunities to engage in health care and healthy behaviors. Despite spending $34 billion annually on the care of patients with end-stage renal disease, the American public and nephrology community remain remarkably complacent about addressing “upstream” factors that influence the prevention, progression, and treatment of chronic kidney diseases. Recently, a growing number...
Source: American Journal of Kidney Diseases - Category: Urology & Nephrology Source Type: research
We present a 64-year-old Hispanic female with a history of hypertension who was referred for chronic kidney disease management. The review of her laboratory tests revealed a serum creatinine of 1.5 –1.8 mg/dL and microalbuminuria (in the presence of a bland urine sediment) in the past year. She denied any history of diabetes, rheumatologic disorders or exposure to intravenous contrast, nonsteroidal anti-inflammatory drugs, herbals, and heavy metals. Serological workup was negative. A renal b iopsy showed diffuse infiltration of glomerulus with pale eosinophilic material strongly positive for Congo red stain and a sim...
Source: Case Reports in Nephrology and Dialysis - Category: Urology & Nephrology Source Type: research
CONCLUSIONS: CVRFs may be present in early CKD, even before the decline in GFR. Routine screening for CVRFs, along with timely intervention, may prevent the progression of CVD and mortality later in life. PMID: 28809621 [PubMed - in process]
Source: South African Medical Journal - Category: African Health Tags: S Afr Med J Source Type: research
Current guidelines on hypertension treatment in chronic kidney disease (CKD) patients discourage combined angiotensin converting enzyme inhibitor (ACEi) and angiotensin II receptor blocker (ARB) use due to the risk of an increased kidney function decline. However, dual compared to single renin-angiotensin system (RAS) blockade may have more efficacy with regard to hypertension and proteinuria. Among incident pre-dialysis patients (CKD 4-5) we compared dual with no or single RAS blockade regarding kidney function decline, and risk of renal replacement therapy (RRT) or death.
Source: Journal of the American Society of Hypertension - Category: Cardiology Authors: Source Type: research
Abstract AIM: Chronic kidney disease (CKD) may be an etiologic cause of aging, hypertension, diabetes mellitus (DM), and metabolic syndrome. However, the influence of these cardiovascular risk factors and their combination on the development of CKD remains controversial. This retrospective study evaluated the influence of cardiovascular risk factors and their combination on the incidence of CKD during a 6-year follow-up period in middle-aged and older males. METHODS: The subjects were 303 males without a history of cardiovascular disease, stroke, renal dysfunction, or dialysis treatment. A biochemical analysi...
Source: Clinical and Experimental Hypertension - Category: Cardiology Authors: Tags: Clin Exp Hypertens Source Type: research
A 51-year-old woman with a history of hypertension, latent tuberculosis (TB) infection (treated with 9 months of isoniazid), a previous episode of idiopathic pancreatitis, and stage 5 chronic kidney disease secondary to primary focal segmental glomerulosclerosis (FSGS) presented for follow-up 1 week after peritoneal dialysis catheter insertion. Her FSGS was initially steroid responsive, but subsequently became refractory to treatment, and she had persistent nephrotic range proteinuria. On examination, she had mild soreness at her peritoneal catheter site and trace edema.
Source: Kidney International - Category: Urology & Nephrology Authors: Tags: Nephrology Image Source Type: research
In this study, we found a low rate of preeclampsia in a low-to-moderate risk cohort, with an incidence of AKI and maternal mortality consistent with reported literature. PMID: 28352008 [PubMed - in process]
Source: Saudi Journal of Kidney Diseases and Transplantation - Category: Urology & Nephrology Authors: Tags: Saudi J Kidney Dis Transpl Source Type: research
This study will be a multicentred, prospective, double-blind, randomised parallel controlled trial for hypertensive CKD patients in China. Patients will be randomised to one of two treatment groups: a combination of benidipine 4–8 mg/day and fosinopril 20 mg/day; or a combination of HCTZ 12.5–25 mg/day and fosinopril 20 mg/day. Patients will be followed up for 24 months after a month's fosinopril run-in. There will be dose-titration after 1 and 2 months. The primary endpoint is changes in estimated glomerular filtration rate (eGFR) from baseline to month 24. Secondary endpoints inc...
Source: BMJ Open - Category: Journals (General) Authors: Tags: Open access, Medical management, Urology Protocol Source Type: research
We thank the authors, Dr Hill and Dr Sayer, for their feedback in response to our article published inQJM: An International Journal of Medicine.1 In principle, we agree with the authors and the recent population-based observational studies2 that chronic use of proton pump inhibitors (PPIs) may adversely affect renal physiology including development and/or progression of chronic kidney disease (CKD). Our earlier work3 applying molecular, cell biological and preclinical models found that PPIs directly inhibit the activity of dimethylarginine dimethylaminohydrolase (DDAH); an enzyme that is expressed in different segments of ...
Source: QJM - Category: Internal Medicine Source Type: research
Abstract Cadmium (Cd) is an environmental toxicant of widespread exposure and pervasive toxicity. Absorption, systemic transport and uptake of Cd are mediated by metal transporters that the body uses for acquisition of physiologically-essential elements, notably of iron, zinc and calcium. Currently, human exposure to Cd is known to damage the kidneys, especially the proximal tubular cells that actively reabsorb Cd along with zinc, glucose and amino acids in the glomerular filtrate. Severe kidney damage, glycosuria and proteinuria are known outcomes after high dietary Cd intake (> 200 µg/day). Dietary Cd i...
Source: The Tohoku Journal of Experimental Medicine - Category: Research Authors: Tags: Tohoku J Exp Med Source Type: research
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