ZIP4 Promotes Pancreatic Cancer Progression by Repressing ZO-1 and claudin-1 through a ZEB1-Dependent Transcriptional Mechanism.

CONCLUSIONS:  These findings suggest a novel pathway activated by ZIP4 controlling pancreatic cancer invasiveness and metastasis, which could serve as a new therapeutic target for this devastating disease.
PMID: 29615456 [PubMed - as supplied by publisher]

Source: Clinical Cancer Research - April 3, 2018 Category: Cancer & Oncology Authors: Liu M, Yang J, Zhang Y, Zhou Z, Cui X, Zhang L, Fung KM, Zheng W, Allard FD, Yee EU, Ding K, Wu H, Liang Z, Zheng L, Fernandez-Zapico ME, Li Y, Bronze MS, Morris KT, Postier RG, Houchen CW, Yang J, Li M Tags: Clin Cancer Res Source Type: research