Mp42-11 excessive risks for developing renal failure after cytoreductive nephrectomy in the metastatic setting

Though radical cytoreductive nephrectomy has been shown to improve overall survival in patients with metastatic renal cell carcinoma, the impact this treatment has on renal function has not been adequately assessed. Radical nephrectomy in patients with localized cancer has been associated with risk of chronic kidney disease development. Using patients enrolled in ADAPT trial that received cytoreductive nephrectomy in the metastatic setting, we intend to study the effect of this procedure on overall renal function in patients without kidney disease.
Source: The Journal of Urology - Category: Urology & Nephrology Authors: Tags: Kidney Cancer: Localized: Surgical Therapy IV Source Type: research

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Conclusions: For patients with suppressed HBV DNA, the efficacy of TDF monotherapy as maintenance therapy is comparable to that of entecavir plus TDF combination therapy. PMID: 30647735 [PubMed]
Source: Gastroenterology Research and Practice - Category: Gastroenterology Tags: Gastroenterol Res Pract Source Type: research
ConclusionsIn Myanmar, generic and pan-genotypic SOF/VEL ± RBV is a highly effective and safe treatment for HCV, regardless of the HCV genotype, and therefore, the requirement for the baseline genotype can be eliminated. Future strategies should include elimination of treatment and end of treatment HCV RNA testing to enhance treatment uptake and further reduce cost.
Source: Journal of Clinical and Experimental Hepatology - Category: Gastroenterology Source Type: research
A 73-year-old female presenting with haemoptysis and dyspnoea was found to have a locally advanced left thyroid mass and vocal cord palsy. A CT scan of the neck and thorax and endoscopy demonstrated invasion into the tracheal lumen. Histopathology of the intraluminal tracheal mass confirmed a papillary thyroid cancer (PTC). The tumour was deemed unresectable due to local extent and patient comorbidities. TKI therapy with lenvatinib was used for 14 months. On serial scanning, a marked reduction in tumour volume from 31 × 59 × 32 mm to 17 × 28 × 22 mm was noted. This subsequently allowed a successful ...
Source: European Thyroid Journal - Category: Endocrinology Source Type: research
This study was a retrospective, multicentre, international study in patients carrying the Met918Thr RET variant with no age restrictions. The study was done with registry data from 48 centres globally. Data from patients followed-up from 1970 to 2016 were retrieved from May 1, 2016, to May 31, 2018. Our primary objectives were to determine overall survival, and medullary thyroid carcinoma-specific survival based on whether the patient had undergone early thyroidectomy before the age of 1 year. We also assessed remission of medullary thyroid carcinoma, incidence and treatment of phaeochromocytoma, and the penetrance of extr...
Source: The Lancet Diabetes and Endocrinology - Category: Endocrinology Source Type: research
Publication date: Available online 16 January 2019Source: Molecular and Cellular EndocrinologyAuthor(s): Irida Kastrati, Svetlana Semina, Benjamin Gordon, Emily SmartAbstractEstrogen receptor (ER) is the most important factor in the pathophysiology of breast cancer. Consequently, modulation of ER activity has been exploited to develop drugs against ER + breast cancer, such as tamoxifen, referred to as endocrine therapies. With deeper understanding of ER mechanism of action, posttranslational modifications (PTMs) are increasingly recognized as important in mediating ER activity. Some ER PTMs such as phosphorylatio...
Source: Molecular and Cellular Endocrinology - Category: Endocrinology Source Type: research
ConclusionsHead and neck manifestations of syphilis have been reported in the literature. However, this is the first series reporting on oropharyngeal syphilis masquerading as HPV-related OPSCC. Ultimately, otolaryngologists must maintain a high suspicion for syphilis in order to ensure prompt diagnosis and treatment.
Source: American Journal of Otolaryngology - Category: Endocrinology Source Type: research
We examined the utility of a neuroendocrine multigene transcript “liquid biopsy” (NETest) in bronchopulmonary carcinoids (BPC) for diagnosis and monitoring of disease status. Aim: To independently validate the utility of the NETest in diagnosis and management of BPC in a multicenter, multinational blinded study. Material and methods: The study cohorts assess ed were bronchopulmonary carcinoids (BPC) (n=99), healthy controls (n=102), other lung neoplasia (n=101) including adenocarcinomas (ACC) (n=41), squamous cell carcinomas (SCC) (n=37), SCLC (n=16) and LCNEC (n=7) and idiopathic pulmonary fibrosis (IPF) (n=5...
Source: Neuroendocrinology - Category: Endocrinology Source Type: research
Publication date: Available online 17 January 2019Source: Journal of Pharmaceutical and Biomedical AnalysisAuthor(s): Heebin Son, Keumhan Noh, Changhyun Kang, MinKyun Na, Sangtaek Oh, Im-Sook Song, Wonku KangAbstractIlimaquinone, a metabolite isolated from the marine sponge Hippiospongia metachromia, has antimicrobial, cytotoxic, anti-HIV, anti-inflammatory, and anti-cancer activities. A new quantitative analytical method for determination of ilimaquinone in rat plasma using HPLC-MS/MS was developed and validated. Ascorbic acid was added to ensure the stability of ilimaquinone in plasma. After protein precipitation using a...
Source: Journal of Pharmaceutical and Biomedical Analysis - Category: Drugs & Pharmacology Source Type: research
Publication date: Available online 17 January 2019Source: PhytomedicineAuthor(s): Wagner B.R. Santos, Marlange A.O. Melo, Rafael S. Alves, Renan G. de Brito, Thallita K. Rabelo, Lindaura da S. Prado, Virginia K. dos S. Silva, Daniel P. Bezerra, José E.R. de Menezes-Filho, Diego S. Souza, Carla M.L. de Vasconcelos, Luciana Scotti, Marcus Tullius Scotti, Waldecy de Lucca Júnior, Lucindo J. Quintans-Júnior, Adriana G. GuimarãesAbstractBackgroundOncological pain is one of the most prevalent and difficult-to-treat symptoms in patients with cancer. p-cymene (PC) is a monoterpene found in more than 100...
Source: Phytomedicine - Category: Drugs & Pharmacology Source Type: research
ConclusionThis is the first report on the antiproliferative activity of flavipin isolated from endophytic C. globosum and also proposed that interaction of flavipin with NFкB could be a possible mechanism for this activity. Flavipin induced apoptosis at low concentrations in cancer cell lines (A549, HT-29) and exhibited itself as a potential anticancer agent.Graphical abstract
Source: Phytomedicine - Category: Drugs & Pharmacology Source Type: research
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