Mp42-11 excessive risks for developing renal failure after cytoreductive nephrectomy in the metastatic setting

Though radical cytoreductive nephrectomy has been shown to improve overall survival in patients with metastatic renal cell carcinoma, the impact this treatment has on renal function has not been adequately assessed. Radical nephrectomy in patients with localized cancer has been associated with risk of chronic kidney disease development. Using patients enrolled in ADAPT trial that received cytoreductive nephrectomy in the metastatic setting, we intend to study the effect of this procedure on overall renal function in patients without kidney disease.
Source: The Journal of Urology - Category: Urology & Nephrology Authors: Tags: Kidney Cancer: Localized: Surgical Therapy IV Source Type: research

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This study investigated the relationship of American Indian boarding school attendance and chronic physical health. We hypothesized boarding school attendance would be associated with an increased number of chronic physical health problems. We also examined the relationship between boarding school attendance and the 15 chronic health problems that formed the count of the chronic health conditions. American Indian attendees had a greater count of chronic physical health problems compared with nonattendees. Father's attendance was independently associated with chronic physical health problems. Attendees were more likely to h...
Source: Family and Community Health - Category: Primary Care Tags: Health Equity Source Type: research
The loss of bone mineral density caused by Chronic Kidney Disease can make the delineation of a patient’s bony anatomy impossible during intra-operative fluoroscopy. This has the potential to increase the failure rate of implants used in the surgical treatment of neck of femur fractures due to sub-optimal placements. Intra-operative arthrograms add to the techniques available to a surgeon to achieve optimal implant placement without compromising the patient’s renal function nor increasing the radiation dose exposure to the surgical team.
Source: Techniques in Orthopaedics - Category: Orthopaedics Tags: Tips and Pearls Source Type: research
Publication date: January 2019Source: Journal of Functional Foods, Volume 52Author(s): Meimei Wang, Hang Ma, Zhaoxing Li, Yang Yu, Liangyu Liu, Xuegang Li, Xiaoli YeAbstractThe aim of this study was to explore the inhibitory effects of SPG-56 and intestinal microbes on the progression of colorectal cancer (CRC). An in-vivo model of CRC was generated by transplanting BALB/c nude mice with HCT-116 cells and tumor progression was monitored after treatment with SPG-56 (150 mg/kg), Lactobacillus fermentum (2 × 108 cfu/0.2 ml) + SPG-56 (150 mg/kg) and short-chain fatty acids (SCFAs, 20 mM/0.2 ml). All thr...
Source: Journal of Functional Foods - Category: Nutrition Source Type: research
Publication date: January 2019Source: Journal of Functional Foods, Volume 52Author(s): Tran Van Hung, Jun Wanatanbe, Yasunori Yonejima, Keiko Hisa, Yoshinari Yamamoto, Takuya SuzukiAbstractFeeding with 10% leucosaccharides for 3 weeks mitigated the development of adenine-induced chronic kidney disease in mice, as assessed by plasma urea, renal expression of inflammatory- and fibrosis-associated molecules, and colonic expression of tight junction proteins. Leucosaccharides are exopolysaccharides produced by Leuconostoc mesenteroides subsp. mesenteroides strain NTM048. Sequencing of 16S rRNA also revealed that leucosacchar...
Source: Journal of Functional Foods - Category: Nutrition Source Type: research
This study aimed to examine the growth inhibitory effect of the lower concentrations of β-carotene in HepG2 cells. Beta-carotene purified from Gracillaria sp. inhibited viability of HepG2 cells in a concentration-dependent manner. This growth inhibitory effect was well correlated with increased apoptotic cell death. Apoptosis induction by β-carotene was associated with increased caspase-3 activity and reduced mitochondrial membrane potential. Western blot analysis showed a significant decrease in the expression of Bcl-2, PARP, and NF-kB protein, and an increase in the protein expression of Bax. Beta-carotene also...
Source: Journal of Functional Foods - Category: Nutrition Source Type: research
Objectives: To identify, appraise, and synthesize current evidence to determine whether early enteral nutrition alters patient outcomes from major burn injury. Data Sources: Medline, Embase, and the China National Knowledge Infrastructure were searched. The close out date was May 1, 2018. Study Selection: Early enteral nutrition was defined as a standard formula commenced within 24 hours of injury or admission to ICU or burn unit. Comparators included any form of nutrition support “except” early enteral nutrition. Only randomized controlled trials reporting patient-centered outcomes were eligible for in...
Source: Critical Care Medicine - Category: Emergency Medicine Tags: Review Articles Source Type: research
Conclusions: Renal Klotho expression in human sepsis-acute kidney injury and in mouse models of sepsis was significantly decreased and correlated with renal damage. Recombinant Klotho intervention diminished organ damage, inflammation, and endothelial activation in the kidney and brain of lipopolysaccharide-challenged mice. Systemic Klotho replacement may potentially be an organ-protective therapy for septic patients to halt acute, inflammatory organ injury.
Source: Critical Care Medicine - Category: Emergency Medicine Tags: Online Laboratory Investigations Source Type: research
CONCLUSIONS The AEG-1/Notch1 signaling axis plays a vital role in ccRCC cell growth and metastasis. PMID: 30431025 [PubMed - in process]
Source: Medical Science Monitor - Category: Research Tags: Med Sci Monit Source Type: research
CONCLUSIONS The results of this research indicate that the metastases of non-small cell lung cancer can predict RET rearrangement of the primary tumor tissue in the majority of cases. Testing for RET rearrangement in metastases can be used as an alternative to testing of primary tumor tissue if it is inaccessible. PMID: 30429449 [PubMed - in process]
Source: Medical Science Monitor - Category: Research Tags: Med Sci Monit Source Type: research
Authors: Akbarzadeh F, Khoshgard K, Arkan E, Hosseinzadeh L, Hemati Azandaryani A Abstract Selective accumulation of photosensitizers (PSs) into cancerous cells is one of the most important factors affecting photodynamic therapy (PDT) efficacy. 5-Aminolevulinic acid (5-ALA) is precursor of a strong PS, protoporphyrin-IX (Pp-IX); but it has poor permeability in lipophilic membrane of the cells due to its hydrophilic property. Therefore, establishment of an improved delivery strategy could highly affect on treatment outcome. Moreover, folate receptors (FRs) are overexpressed on the surface of many tumor cells. In the...
Source: Artificial Cells, Nanomedicine and Biotechnology - Category: Biotechnology Tags: Artif Cells Nanomed Biotechnol Source Type: research
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