Pd46-10 characterization of chimeric tfe3 transcription factors found in xp11.2 translocation renal cell carcinoma

Xp11.2 translocation renal cell carcinoma (Xp11.2 tRCC) is a newly defined subset of RCC which is characterized by various translocations involving chromosome Xp11.2. All the Xp11.2 translocations produce chimeric TFE3 genes, which retain the coding sequences for the basic helix-loop-helix leucine zipper structure (bHLH-Zip) through which TFE3 binds to DNA. It is suggested that the TFE3 fusion proteins encoded by the chimeric TFE3 genes work as constitutively active transcription factors resulting in Xp11.2 tRCC development.

Source: The Journal of Urology - April 1, 2018 Category: Urology & Nephrology Authors: Takanobu Motoshima, Yorifumi Satou, Paola Miyazato, Hisashi Hasumi, Ying Huang, Tsuyoshi Kadomatsu, Masahiro Yao, Yoji Nagashima, Mitsuko Furuya, Yuchi Oike, Laura S Schmidt, Tomomi Kamba, W Marston Linehan, Masaya Baba Tags: Kidney Cancer: Basic Research & Pathophysiology I Source Type: research