The Long-Term Clinical Outcome of Posttraumatic Stress Disorder With Impaired Coronary Distensibility

This study investigated the relation of impaired CDI with posttraumatic stress disorder (PTSD) and their predictive value for major adverse cardiovascular events (MACE). Methods This study involved 246 patients (age = 63 [10] years, 12% women) with (n = 50) and without (n = 196) PTSD, who underwent computed tomography angiography to determine coronary artery disease and CDI. Extent of coronary artery disease was defined as normal, nonobstructive (50%). Incidence of MACE, defined as myocardial infarction or cardiovascular death, was documented during a mean follow-up of 50 months. Survival regression was employed to assess the longitudinal association of impaired CDI and PTSD with MACE. Results A significant inverse correlation between CDI and Clinical Global Impression Severity scale of PTSD symptoms was noted (r2 = .81, p = .001). CDI was significantly lower in patients with PTSD (3.3 [0.2]) compared with those without PTSD (4.5 [0.3]), a finding that was more robust in women (p
Source: Psychosomatic Medicine - Category: Psychiatry & Psychology Tags: Original Articles Source Type: research