HeartEn Bloc Thymus Cotransplantation in NHPs Controls Cellular but not Humoral Alloreactivity

We have achieved tolerance of cardiac allografts in cynomolgus monkeys for the first time by using a mixed chimerism-based conditioning protocol and by co-transplanting a donor kidney. The mechanism by which a kidney confers tolerance upon a heart is unclear. To gain mechanistic insight and at the same time develop a clinically relevant tolerance protocol, we investigated whether a vascularized donor thymus could substitute for the donor kidney.

Source: The Journal of Heart and Lung Transplantation - March 31, 2018 Category: Transplant Surgery Authors: J.O.W. Sommer, K. Pruner, J.T. Paster, I.M. Hanekamp, A. Dehnadi, I. Rosales, R.N. Smith, R.B. Colvin, G. Benichou, J.S. Allan, J.C. Madsen Source Type: research