Leptin Modifies the Impact of BMI on Heart Failure Progression: The Obesity Paradox Unraveling

Leptin is secreted by adipocytes, induces satiety via central mechanisms, and stimulates lipolysis and fatty acid utilization. Cardiac cachexia has been associated with worse outcomes in chronic heart failure (HF), and the role of leptin is poorly understood. We hypothesized that patients in chronic HF with low leptin levels would have worse outcomes and that leptin would modify the relationship of body mass index (BMI) with HF progression.

Source: The Journal of Heart and Lung Transplantation - March 31, 2018 Category: Transplant Surgery Authors: J.E. Rame, J.M. Ortega-Legaspi, A. Cappola, K.R. Dumon, T.P. Cappola Source Type: research