Distinct Phenotypic, Molecular and Immune Characteristics of Circulating Exosomes From Lung Transplant Recipients With Bronchiolitis Obliterans Syndrome versus Stable Patients

Circulating exosomes isolated from lung transplant recipients (LTxR) with bronchiolitis obliterans syndrome (BOS), but not stable, contained donor HLA and lung self-antigens (SAgs), Collagen V (Col-V) and K α1Tubulin (Kα1T), supporting that exosomes induce immune responses leading to BOS. We defined the differences in phenotypic and molecular characteristics of exosomes (BOS vs stable) towards determining their immunogenicity.

Source: The Journal of Heart and Lung Transplantation - March 31, 2018 Category: Transplant Surgery Authors: M. Gunasekaran, M. Sharma, F. Rodriguez, S. Elnahas, R. Hachem, R. Walia, M. Smith, R. Bremner, T. Mohanakumar Source Type: research