Altered lactate metabolism in Huntington's disease is dependent on GLUT3 expression.

CONCLUSION: We demonstrate that stimulation of lactate uptake by ascorbic acid is a consequence of inhibiting glucose transport. Supporting this, lactate transport stimulation by ascorbic acid in HD cells was completely restored by overexpressing GLUT3. Therefore, alterations in GLUT3 expression could be responsible for inefficient use of lactate in HD neurons, contributing to the metabolic failure observed in HD.
PMID: 29582588 [PubMed - in process]

Source: CNS Neuroscience and Therapeutics - March 29, 2018 Category: Neuroscience Authors: Solís-Maldonado M, Miró MP, Acuña AI, Covarrubias-Pinto A, Loaiza A, Mayorga G, Beltrán FA, Cepeda C, Levine MS, Concha II, Bátiz LF, Carrasco MA, Castro MA Tags: CNS Neurosci Ther Source Type: research