Association between sperm mitochondrial ND2 gene variants and total fertilization failure.

This study suggests that the MT-ND2 gene variants might not be associated with TFF.
ABBREVIATIONS: ATP: adenosine triphosphate; dNTP: deoxy-ribonucleoside triphosphate; FADH2: flavin adenine dinucleotide; FDR: false discovery rate; FSH: follicle-stimulating hormone; IVF: in vitro fertilization; LH: luteinizing hormone; MTATP6: mitochondrially encoded ATP synthase 6; MTCYB: mitochondrially encoded cytochrome b; mtDNA: mitochondrial DNA; MT-ND2: mitochondrial ND2; NADH: nicotinamide adenine dinucleotide; ND2: NADH dehydrogenase subunit 2; OXPHOS: oxidative phosphorylation; PCR: single nucleotide polymorphisms; SNPs: single nucleotide polymorphisms; TFF: total fertilization failure.
PMID: 29577757 [PubMed - as supplied by publisher]

Source: Systems Biology in Reproductive Medicine - March 26, 2018 Category: Reproduction Medicine Authors: Zhang JL, Mao GH, Huang XH, Chang HY, Zheng Y, Cao X Tags: Syst Biol Reprod Med Source Type: research