Transcription factor specificity protein 1 modulates TGF β1/Smad signaling to negatively regulate SIGIRR expression by human M1 macrophages stimulated with substance P.

In conclusion, TGFβ1 may be an intermediary between SP/NK1R activation and SIGIRR expression in Sp1 siRNA-transfected macrophages. In addition, Sp1 modulates TGFβ1/Smad signaling and negatively regulates SIGIRR protein production by macrophages after SP stimulation.
PMID: 29558695 [PubMed - as supplied by publisher]

Source: Cytokine - March 17, 2018 Category: Molecular Biology Authors: Yamaguchi R, Sakamoto A, Yamaguchi R, Haraguchi M, Narahara S, Sugiuchi H, Yamaguchi Y Tags: Cytokine Source Type: research