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Combining drug and music therapy in patients with moderate Alzheimer ’s disease: a randomized study

This study aimed to clarify whether adding AMT to M may improve language in comparison with drugs alone in patients with moderate AD on stable therapy with acetylcholinesterase inhibito rs (AchEI). Forty-five AD patients treated with stable dose of AchEI were randomized to receive AMT plus M 20 mg/day or M 20 mg/day for 24 weeks. The Severe Impairment Battery-Language (SIB-l), SIB, Mini Mental State Examination, Neuropsychiatric Inventory (NPI), Lubben Social Network Scale, Acti vities of Daily Living, and Instrumental Activities of Daily Living scores at baseline and 12 and 24 weeks assessed language (primary variable) and overall cognitive, psycho-behavior, social, and functional aspects (secondary variables). The SIB-l showed a stabilization of the baseline condition in both groups, in the absence of between-group differences. The NPI depression and appetite scores significantly improved in the M-AMT group. Moreover, significantly less patients in the M-AMT group than those in the M group showed worsening of the NPI total score. Daily activities, social relationsh ips, and overall cognitive performance did not deteriorate. In patients with moderate AD, AMT added to pharmacotherapy has no further benefits for language in comparison with pharmacotherapy alone. However, this integrated treatment can improve the psycho-behavioral profile.
Source: Neurological Sciences - Category: Neurology Source Type: research

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The purpose of this study was to investigate the effect of an 8-week nursing intervention consisting of 2 weekly sessions of music and reminiscence therapy together with the application of reality orientation techniques. Our expectation at the onset of the study was that listening to music that was familiar and connected with the memory of past events would, due to the music's emotional impact, stimulate memory associations, leading, in turn, to a positive effect on depression and anxiety in people living with dementia. We carried out a pre-/posttest intervention design with a sample of 19 patients divided into 2 groups&md...
Source: Holistic Nursing Practice - Category: Nursing Tags: Features Source Type: research
CONCLUSIONS: Music therapy constitutes a non-pharmacological therapy effective for some cognitive, emotional and behavioral symptoms in patients with AD. However, further investigations and more evidence in this field are needed to claim conclusively the impact of music therapy on this disease. PMID: 29235615 [PubMed - in process]
Source: Revista de Neurologia - Category: Neurology Authors: Tags: Rev Neurol Source Type: research
The purpose of this study was to investigate the effect of an 8-week nursing intervention consisting of 2 weekly sessions of music and reminiscence therapy together with the application of reality orientation techniques. Our expectation at the onset of the study was that listening to music that was familiar and connected with the memory of past events would, due to the music's emotional impact, stimulate memory associations, leading, in turn, to a positive effect on depression and anxiety in people living with dementia. We carried out a pre-/posttest intervention design with a sample of 19 patients divided into 2 groups&md...
Source: Holistic Nursing Practice - Category: Nursing Tags: Features Source Type: research
The Journal of Alternative and Complementary Medicine , Vol. 0, No. 0.
Source: The Journal of Alternative and Complementary Medicine - Category: Complementary Medicine Authors: Source Type: research
AbstractThis controlled randomized single-blind study evaluated the effects of cognitive training (CT), compared to active music therapy (AMT) and neuroeducation (NE), on initiative in patients with mild to moderate Alzheimer ’s disease (AD). Secondarily, we explored the effects of CT on episodic memory, mood, and social relationships. Thirty-nine AD patients were randomly assigned to CT, AMT, or NE. Each treatment lasted 3 months. Before, at the end, and 3 months after treatment, neuropsychological tests and self-ra ted scales assessed initiative, episodic memory, depression, anxiety, and social relationsh...
Source: Neurological Sciences - Category: Neurology Source Type: research
Conclusions Although there are reports of the efficacy of music therapy on the decline of neuropsychiatric symptoms of dementia, the area still needs randomized studies aimed at the solution of important methodological problems like the lack of standardized approaches.RESUMO Objetivo Muitas interven ções psicossociais na demência estão baseadas em atividades musicais e intervenções de musicoterapia. Nosso objetivo consiste em avaliar a eficácia das intervenções de musicoterapia nos sintomas neuropsiquiátricos de pessoas com demência. Métodos ...
Source: Jornal Brasileiro de Psiquiatria - Category: Psychiatry Source Type: research
Conclusions Although there are reports of the efficacy of music therapy on the decline of neuropsychiatric symptoms of dementia, the area still needs randomized studies aimed at the solution of important methodological problems like the lack of standardized approaches.RESUMO Objetivo Muitas interven ções psicossociais na demência estão baseadas em atividades musicais e intervenções de musicoterapia. Nosso objetivo consiste em avaliar a eficácia das intervenções de musicoterapia nos sintomas neuropsiquiátricos de pessoas com demência. Métodos ...
Source: Jornal Brasileiro de Psiquiatria - Category: Psychiatry Source Type: research
Conclusions In the sample studied, music therapy improved some cognitive, psychological, and behavioural alterations in patients with AD. Combining music therapy with dance therapy to improve motor and functional impairment would be an interesting line of research.
Source: Neurologia - Category: Neurology Source Type: research
"I have a black eye, but I'm hanging in there." Kim Campbell, tells me. "Caregiving is hard," she says. "I don't know how people do it." Kim's husband, legendary country singer, Glen Campbell, rocked awareness when he and his family let the world know their secret. Together they toured the country after bravely announcing he had Alzheimer's diseaselen playing his heart out with his musically talented children: son, Shannon and daughter, Ashley, by his side. Napa Valley was their final stage, Glen's last encore. By that night, his struggle through the plaques and tangles plaguing his brain had...
Source: Healthy Living - The Huffington Post - Category: Consumer Health News Source Type: news
Publication date: Available online 22 January 2016 Source:European Geriatric Medicine Author(s): D.M. Cammisuli, S. Danti, F. Bosinelli, G. Cipriani Currently, non-pharmacological interventions are useful, versatile and potentially cost-effective tools for managing the care of people suffering from Alzheimer's Disease (AD). The aim of the present study is to examine non-pharmacological interventions in terms of their theoretical basis and empirical evidence in improving cognition and autonomy of daily living and reducing neuropsychiatric symptoms in people with AD. We searched the electronic databases from January 20...
Source: European Geriatric Medicine - Category: Geriatrics Source Type: research
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