Rapid Advances in Immunotherapy to Treat Cancer.

Rapid Advances in Immunotherapy to Treat Cancer.
Clin Pharmacol Ther. 2018 Apr;103(4):540-544
Authors: McCune JS
Abstract
Immunotherapy is now the fourth pillar of cancer therapy, with surgery, radiation, and traditional chemotherapy being the remaining pillars. Over the past decade, enthusiasm for immunotherapy has increased because of, in part, data showing that it consistently improves overall survival in select patients with historically refractory cancers. This issue covers various aspects of immunotherapy ranging from use of 1) chimeric antigen receptor (CAR) T cells to treat patients with B-cell acute lymphoblastic leukemia; 2) population pharmacokinetic/dynamic modeling to develop new immune checkpoint inhibitors; and 3) simulations of existing population pharmacokinetic models of immunotherapy to minimize waste without compromising exposure and efficacy.
PMID: 29527663 [PubMed - in process]

Source: Clinical Pharmacology and Therapeutics - March 14, 2018 Category: Drugs & Pharmacology Authors: McCune JS Tags: Clin Pharmacol Ther Source Type: research