In silico studies targeting G-protein coupled receptors for drug research against Parkinson's disease.

In silico studies targeting G-protein coupled receptors for drug research against Parkinson's disease. Curr Neuropharmacol. 2018 Mar 08;: Authors: Lemos A, Meloc R, Preto AJ, Almeida JG, Moreira IS, Cordeiro MNDS Abstract Parkinson's Disease (PD) is a long-term neurodegenative brain disorder that mainly affects the motor system. The causes are still unknown, and even though currently there is no cure, several therapeutic options are available to manage its symptoms. The development of novel anti-parkinsonian agents and an understanding of their proper and optimal use are, indeed, highly demanding. For the last decades, L-3,4-DihydrOxyPhenylAlanine or levodopa (L-DOPA) has been the gold-standard therapy for the symptomatic treatment of motor dysfunctions associated to PD. However, the development of dyskinesias and motor fluctuations (wearing-off and on-off phenomena) associated to long-term L-DOPA replacement therapy have limited its antiparkinsonian efficacy. The investigation for non-dopaminergic therapies has been largelyexplored as an attempt to counteract the motor side effects associated to dopamine replacement therapy. Being one of the largest cell membrane protein families, G-Protein-Coupled Receptors (GPCRs) have become a relevant target for drug discovery focused in a wide range of therapeutic areas, including Central Nervous System (CNS) diseases. The modulation of specific GPCRs potentially implicated in PD, excluding dopamine receptors, may ...
Source: Current Neuropharmacology - Category: Drugs & Pharmacology Authors: Tags: Curr Neuropharmacol Source Type: research

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CONCLUSIONS: While addressing individual factors associated with sleep disturbances, it is also important to emphasize the needs arising from the patient-carer dyadic relationship. While a number of non-pharmacological interventions were suggested in the literature, further well-controlled trials are still required. CLINICAL IMPLICATIONS: Multiple approaches are required to reduce sleep disturbances and associated burden in PD. PMID: 30422081 [PubMed - as supplied by publisher]
Source: Clinical Gerontologist - Category: Geriatrics Tags: Clin Gerontol Source Type: research
In Parkinson's disease, toxic protein clumps accumulate in the brain's motor region. A study shows how targeting an enzyme could prevent this.
Source: Health News from Medical News Today - Category: Consumer Health News Tags: Parkinson's Disease Source Type: news
PARKINSON ’S disease symptoms include tremors, slow movement and muscle stiffness. But there are other warning signs and symptoms of the neurodegenerative brain condition you should be aware of. Do you sleep like this? How to reveal your risk of Parkinson’s disease while you’re asleep.
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
Abstract Summary: Provision of initial surgery to casualties within one hour of injury is associated with better survival. Where evacuation options are limited, surgery within the “golden hour” may have to occur close to the point of injury. Interventions close to the point of injury are limited by the adverse environment. Far-forward surgery has a long history going back to Dominique Larrey of the Napoleonic Army. We reviewed previous reports and used our own experience of far-forward surgery to describe the specifications of the ideal mobile operating room that would address some of these environment...
Source: Canadian Journal of Surgery - Category: Surgery Authors: Tags: Can J Surg Source Type: research
Publication date: Available online 13 November 2018Source: Saudi Pharmaceutical JournalAuthor(s): Yong Chon Park, Min-Soo Lee, Tian-Mei Si, Helen F.K. Chiu, Shigenobu Kanba, Mian-Yoon Chong, Adarsh Tripathi, Pichet Udomratn, Kok Yoon Chee, Andi J. Tanra, Golam Rabbani, Afzal Javed, Samudra Kathiarachchi, Win Aung Myint, Tran Van Cuong, Kang Sim, Shu-yu Yang, Norman Sartorius, Chay-Hoon Tan, Naotaka ShinfukuAbstractBackgroundAlthough disorganized speech is seen as one of the nuclear features of schizophrenia, there have been few reports of disorganized speech-associated psychotropic drug-prescribing patterns in large sample...
Source: Saudi Pharmaceutical Journal - Category: Drugs & Pharmacology Source Type: research
Publication date: Available online 13 November 2018Source: International Review of NeurobiologyAuthor(s): Rezzak Yilmaz, Daniela BergAbstractApplying a 2–4 MHz probe at the temporal bone window transcranial B-mode sonography (TCS) enables the depiction of the brain parenchyma through the intact skull. Meanwhile it has been applied for the diagnosis and the differential diagnosis of movement disorders for decades. In the first part of this chapter, we summarize the technical requirements and describe the ultrasound method for optimal TCS examination. Imaging planes and the relevant structures are explained in det...
Source: International Review of Neurobiology - Category: Neuroscience Source Type: research
Michaela D. Gjerstad, Guido Alves, Jodi Maple-Gr ødem
Source: Frontiers in Neurology - Category: Neurology Source Type: research
Researchers from Georgetown University Medical Center in Washington DC have discovered blocking a certain protein in the brain can clear away nerve damaging build-ups.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
(Georgetown University Medical Center) A team of neurologists at Georgetown University Medical Center has found that inhibiting the USP13 molecule may be a therapeutic target in Parkinson's disease and other similar forms of neurodegeneration.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news
(Bentham Science Publishers) The fourth volume of this series features five chapters covering natural lead compounds, computer aided drug discovery methods in Parkinson's Disease therapy, studies of aminoacyl tRNA synthetase inhibition in bacteria, computational modeling of halogen bonds in biological systems and molecular classification of caffeine and its metabolites.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news
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