In silico studies targeting G-protein coupled receptors for drug research against Parkinson's disease.

In silico studies targeting G-protein coupled receptors for drug research against Parkinson's disease. Curr Neuropharmacol. 2018 Mar 08;: Authors: Lemos A, Meloc R, Preto AJ, Almeida JG, Moreira IS, Cordeiro MNDS Abstract Parkinson's Disease (PD) is a long-term neurodegenative brain disorder that mainly affects the motor system. The causes are still unknown, and even though currently there is no cure, several therapeutic options are available to manage its symptoms. The development of novel anti-parkinsonian agents and an understanding of their proper and optimal use are, indeed, highly demanding. For the last decades, L-3,4-DihydrOxyPhenylAlanine or levodopa (L-DOPA) has been the gold-standard therapy for the symptomatic treatment of motor dysfunctions associated to PD. However, the development of dyskinesias and motor fluctuations (wearing-off and on-off phenomena) associated to long-term L-DOPA replacement therapy have limited its antiparkinsonian efficacy. The investigation for non-dopaminergic therapies has been largelyexplored as an attempt to counteract the motor side effects associated to dopamine replacement therapy. Being one of the largest cell membrane protein families, G-Protein-Coupled Receptors (GPCRs) have become a relevant target for drug discovery focused in a wide range of therapeutic areas, including Central Nervous System (CNS) diseases. The modulation of specific GPCRs potentially implicated in PD, excluding dopamine receptors, may ...
Source: Current Neuropharmacology - Category: Drugs & Pharmacology Authors: Tags: Curr Neuropharmacol Source Type: research

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Authors: Umemoto G, Furuya H Abstract Various methods of rehabilitation for dysphagia have been suggested through the experience of treating stroke patients. Although most of these patients recover their swallowing function in a short period, dysphagia in Parkinson's disease (PD) and Parkinson-related disorder (PRD) degenerates with disease progression. Muscle rigidity and bradykinesia are recognized as causes of swallowing dysfunction, and it is difficult to easily apply the strategies for stroke to the rehabilitation of dysphagia in PD patients. Disease severity, weight loss, drooling, and dementia are important ...
Source: Internal Medicine - Category: Internal Medicine Tags: Intern Med Source Type: research
Freezing of gait (FoG) is a common type of motor dysfunction in advanced Parkinson's disease (PD) associated with falls. Over the last decade, a significant amount of studies has been focused on detecting FoG episodes in clinical and home environments. Yet...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Elder Adults Source Type: news
Publication date: Available online 18 April 2019Source: Journal of Sport and Health ScienceAuthor(s): Xin Luan, Xiangyang Tian, Haixin Zhang, Rui Huang, Na Li, Peijie Chen, Ru WangAbstractA growing understanding of the benefits of exercise over the past few decades has prompted researchers to take an interest in the possibilities of exercise therapy. Because each sport has its own set of characteristics and physiological complications that tend to appear during exercise training, the effects and underlying mechanisms of exercise remain unclear. Thus, the first step in probing exercise effects on different diseases is the s...
Source: Journal of Sport and Health Science - Category: Sports Medicine Source Type: research
Publication date: 2019Source: European Journal of Radiology Open, Volume 6Author(s): Surrin S. Deen, Frank Riemer, Mary A. McLean, Andrew B. Gill, Joshua D. Kaggie, James T. Grist, Robin Crawford, John Latimer, Peter Baldwin, Helena M. Earl, Christine A. Parkinson, Sarah A. Smith, Charlotte Hodgkin, Elizabeth Moore, Mercedes Jimenez-Linan, Cara R. Brodie, Helen C. Addley, Susan J. Freeman, Penelope L. Moyle, Evis SalaAbstractThe aim of this study was to assess the feasibility of rapid sodium MRI (23Na-MRI) for the imaging of peritoneal cancer deposits in high grade serous ovarian cancer (HGSOC) and to evaluate the relation...
Source: European Journal of Radiology Open - Category: Radiology Source Type: research
Obsessive-compulsive disorder (OCD) is common and can be profoundly debilitating. Deep brain stimulation (DBS) —the delivery of high-frequency stimulation via electrodes to neural targets—is safe and effective for the treatment of refractory OCD (1,2). DBS has been approved by the United States Food and Drug Administration for treatment of Parkinson's disease since 2002 and OCD since 2009. Although this treatment is effective on a group level, why specific patients respond but others less so remains an open question.
Source: Biological Psychiatry - Category: Psychiatry Authors: Tags: Commentary Source Type: research
Publication date: 1 July 2019Source: Journal of Molecular Liquids, Volume 285Author(s): Asra Nasir Khan, Md Nadir Hassan, Rizwan Hasan KhanAbstractMetal ions play a vital role in the aggregation of proteins by interfering with their correct folding, thereby affecting protein homeostasis and cell viability, leading to neurodegenerative diseases like Alzheimer's and Parkinson's. Development of therapeutics against protein misfolding diseases has become one of the widely studied areas of research. Till date, all advances in neurodegenerative diseases' therapeutics help symptomatically but do not prevent the root cause of the ...
Source: Journal of Molecular Liquids - Category: Molecular Biology Source Type: research
INTRODUCTION: Gait and balance disorders are common clinical features of Parkinson's disease (PD). Although falls significantly affect the activities of daily living (ADL) and quality of life (QOL) of patients with PD, the underlying neural mechanisms asso...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Elder Adults Source Type: news
Condition:   Parkinson Disease Intervention:   Device: Werable sensors Sponsors:   Fondazione Don Carlo Gnocchi Onlus;   Policlinico Universitario Agostino Gemelli;   Catholic University of the Sacred Heart Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conditions:   Parkinson Disease;   Exercise Training;   Cognitive Change Interventions:   Behavioral: SMARTfit training;   Behavioral: Conventional physical training Sponsors:   University of Southern California;   University of California, Irvine Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Adam and Laura Parkinsons were charged $3,700 after Laura gave birth to their son last year. The couple had chose an in-network hospital, but got an uncovered anesthesiologist.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
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