Topical discoveries on multi-target approach to manage Alzheimer's Disease.

Topical discoveries on multi-target approach to manage Alzheimer's Disease. Curr Drug Metab. 2018 Mar 05;: Authors: Batool A, Kamal MA, Rizvi SMD, Rashid S Abstract Alzheimer's disease (AD) is recognized as progressive multifaceted and multi-factorial neurodegenerative disorder which causes dementia among elderly people. Although, researchers in this field have put considerable efforts for the investigation of novel and appropriate therapeutic measures towards the cure of AD, unfortunately, no effective prevention therapy for this disease is available till date. In fact, various aspects involved in the onset and progression of AD are still disputed or uncovered. However, to achieve definite and direct cure of AD, researcher's attention has been drawn towards exploration of new therapeutics targets. In this review, we have discussed the current progress of various aspects of pathophysiological mechanisms behind AD, together with recent investigational therapeutic approaches and present tools with an emphasis on Multi Target Directed Drugs approach. The review includes significant research findings and success achieved in the last decade pertinent to the application of Multi Target Directed Drugs in the treatment of AD, along with the brief overview of the major drawbacks of conventional drugs. The present review might be helpful for physician, neurologist and scientist in understanding the diverse roots of AD for designing primary cur...
Source: Current Drug Metabolism - Category: Drugs & Pharmacology Authors: Tags: Curr Drug Metab Source Type: research