PGE2-EP3 signaling exacerbates hippocampus-dependent cognitive impairment after laparotomy by reducing expression levels of hippocampal synaptic plasticity-related proteins in aged mice.

CONCLUSION: This study showed that PGE2-EP3 signaling pathway was involved in the progression of POCD and identified EP3 receptor as a promising treatment target. PMID: 29488342 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/29488342?dopt=Abstract

Source: CNS Neuroscience and Therapeutics - February 27, 2018 Category: Neuroscience Authors: Xiao JY, Xiong BR, Zhang W, Zhou WC, Yang H, Gao F, Xiang HB, Manyande A, Tian XB, Tian YK Tags: CNS Neurosci Ther Source Type: research