Helicobacter pylori -induced modulation of the promoter methylation of Wnt antagonist genes in gastric carcinogenesis

ConclusionEpigenetic silencing of SFRP and DKK family genes may facilitate the formation of an epigenetic field duringH. pylori-associated gastric carcinogenesis. The epigenetic field may not be reversed even afterH. pylori eradication except by DKK3 methylation.

Source: Gastric Cancer - March 1, 2018 Category: Gastroenterology Source Type: research