Versatility of Cancer Associated Fibroblasts: Commendable Targets For Anti-Tumor Therapy.

CONCLUSION: The potential role of CAF in anti-tumor therapy is based on its coherent response against drugs, targeting different tumor sections through these genetically more stable and anti-immuno-supportive CAF cells. CAF can be targeted through immunity system; growth factors (GF) including Transforming growth factor (TGF), vascular endothelial GF, fibroblast GF, platelet derived GF; and TME elements including hypoxia, carbonic anhydrase, extracellular matrix (ECM). Collectively these features of CAF make it most vulnerable against single as well as combinational, anti-tumor therapy for synergistic or additive effects. Potential activities of CAF, their origination mechanisms and identification of meticulous bio-markers are needed to be investigated further. The rousing facts about them mutually culminate the anticipation of progress towards novel therapeutic establishment against cancer through CAFs that are under progressive research at all levels including, pre-clinical and clinical trials as well as possess much potential to be explored further. PMID: 29468965 [PubMed - as supplied by publisher]
Source: Current Drug Targets - Category: Drugs & Pharmacology Authors: Tags: Curr Drug Targets Source Type: research