GSE98230 RNA-Seq of treatment response of platinum sensitive and platinum resistant ovarian cancer cells

Contributors : Sarah Schott ; Pauline Wimberger ; Barbara Klink ; Konrad Gr ützmann ; Julian Puppe ; Ulrike S Wauer ; Daniel Klotz ; Evelin Schröck ; Jan D KuhlmannSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensResistance to platinum-based chemotherapy is a clinical challenge in the treatment of ovarian cancer (OC) and limits survival. Therefore, innovative drugs against platinum-resistance are urgently needed. Our therapeutic concept is based on the conjugation of two chemotherapeutic compounds to a monotherapeutic pro-drug, which is taken up by cancer cells and cleaved into active cytostatic metabolites. Here, we explore the activity of the duplex-prodrug 5-FdU-ECyd, covalently linking 2'-deoxy-5-fluorouridine (5-FdU) and 3'-C-ethynylcytidine (ECyd), on platinum-resistant  OC cells. RNA-Sequencing was used for characterization of 5-FdU-ECyd treated platinum-sensitive A2780 and isogenic platinum-resistant A2780cis.
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research