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Blood-thinning drugs designed to cut stroke risk may actually increase it

Scientists call for caution in prescribing anticoagulants after some patients with other conditions found to suffer more strokesBlood-thinning drugs may increase rather than cut the risk of stroke in some people over 65 who have an irregular heartbeat and also chronic kidney disease, according to a new study.The researchers are calling on doctors to be more cautious in prescribing the drugs, called anticoagulants, until there has been more research.Continue reading...
Source: Guardian Unlimited Science - Category: Science Authors: Tags: Medical research Stroke Drugs Health Science Society Doctors Source Type: news

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Authors: Ha KH, Kim B, Shin HS, Lee J, Choi H, Kim HC, Kim DJ Abstract BACKGROUND AND OBJECTIVES: To compare cardiovascular disease (CVD) risk associated with 5 different dipeptidyl peptidase-4 inhibitors (DPP-4is) in people with type 2 diabetes. METHODS: We identified 534,327 people who were newly prescribed sitagliptin (n=167,157), vildagliptin (n=67,412), saxagliptin (n=29,479), linagliptin (n=220,672), or gemigliptin (n=49,607) between January 2013 and June 2015 using the claims database of the Korean National Health Insurance System. A Cox proportional hazards model was used to estimate hazard ratios (HRs)...
Source: Korean Circulation Journal - Category: Cardiology Tags: Korean Circ J Source Type: research
Purpose of review Patients with chronic kidney disease (CKD) are at increased risk of atrial fibrillation, stroke, and bleeding posing unique clinical challenges. Novel oral anticoagulants (NOACs) including dabigatran, rivaroxaban, and apixaban have become recognized as alternative therapy to Vitamin K Antagonists (VKA) regarding the prevention of venous thromboembolism (VTE) and reduce the risk of stroke in atrial fibrillation. However, the understanding of NOACs in CKD is still underdeveloped. This review summarizes recent literature on the efficacy and safety of NOACs in patients with CKD. Recent findings Studies f...
Source: Current Opinion in Nephrology and Hypertension - Category: Urology & Nephrology Tags: EPIDEMIOLOGY AND PREVENTION: Edited by Navdeep Tangri Source Type: research
ConclusionCKD of any stage was associated with an increased risk of postoperative major complication, and severe CKD was associated with increased mortality among patients undergoing pancreatectomy for malignancy. These associations were not diminished in elderly patients. Our findings could inform preoperative counseling and decision-making.
Source: Journal of Gastrointestinal Surgery - Category: Surgery Source Type: research
Conclusion A great impact on death, but not ischemic stroke, was observed in non-anticoagulated hemodialysis patients with AF in comparison to those without AF from the analysis of the RAKUEN study. PMID: 29607945 [PubMed - as supplied by publisher]
Source: Internal Medicine - Category: Internal Medicine Tags: Intern Med Source Type: research
(Natural News) Healthcare professionals usually suggest a sufficient potassium intake to lower an individual’s blood pressure and the risk of cardiovascular damage, coronary heart disease, and stroke. But according to a review, for patients with advanced chronic kidney disease (CKD) and those with end stage renal disease (ESRD), potassium intake must be carefully controlled to prevent...
Source: NaturalNews.com - Category: Consumer Health News Source Type: news
The risk of both stroke and haemorrhage increases as chronic kidney disease progresses, which can complicate the decision on whether to begin anticoagulation in those with concomitant atrial fibrillation.
Source: Clinical Pharmacist - Category: Drugs & Pharmacology Source Type: research
by Laura M. Raffield, Jacob C. Ulirsch, Rakhi P. Naik, Samuel Lessard, Robert E. Handsaker, Deepti Jain, Hyun M. Kang, Nathan Pankratz, Paul L. Auer, Erik L. Bao, Joshua D. Smith, Leslie A. Lange, Ethan M. Lange, Yun Li, Timothy A. Thornton, Bessie A. Young, Goncalo R. Abecasis, Cathy C. Laurie, Deborah A. Nickerson, Steven A. McCarroll, Adolfo Correa, James G. Wilson, NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium, Hematology&Hemostasis, Diabetes, and Structural Variation TOPMed Working Groups , Guillaume Lettre, Vijay G. Sankaran, Alex P. Reiner Co-inheritance of α-thalassemia has a significant p...
Source: PLoS Genetics - Category: Genetics & Stem Cells Authors: Source Type: research
Source: BMJ - Category: General Medicine Source Type: research
Authors: Lin TC, Lu TM, Huang FC, Hsu PF, Shih CC, Lin SJ, Hsu CP Abstract Percutaneous coronary intervention (PCI) has emerged as an alternative treatment to coronary artery bypass grafting (CABG) in patients with unprotected left main coronary artery disease (ULMCAD). However, the optimal treatment for ULMCAD concomitant with chronic kidney disease (CKD) was rarely addressed. Herein, we compare the long-term outcomes of these patients treated with CABG or PCI.From January 2004 to December 2010, 185 patients with ULMCAD and CKD undergoing PCI (n = 84) or CABG (n = 101) were matched for the selection criteria. The ...
Source: International Heart Journal - Category: Cardiology Tags: Int Heart J Source Type: research
In conclusion, senescence of vascular cells promotes the development of age-related disorders, including heart failure, diabetes, and atherosclerotic diseases, while suppression of vascular cell senescence ameliorates phenotypic features of aging in various models. Recent findings have indicated that specific depletion of senescent cells reverses age-related changes. Although the biological networks contributing to maintenance of homeostasis are extremely complex, it seems reasonable to explore senolytic agents that can act on specific cellular components or tissues. Several clinical trials of senolytic agents are currentl...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
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