Targeting tumour hypoxia: shifting focus from oxygen supply to demand.

Targeting tumour hypoxia: shifting focus from oxygen supply to demand. Br J Radiol. 2018 Feb 13;:20170843 Authors: Coates J, Skwarski M, Higgins GS Abstract Tumour hypoxia is a well-recognised barrier to anti-cancer therapy and represents one of the best validated targets in oncology. Previous attempts to tackle hypoxia have focussed primarily on increasing tumour oxygen supply; however, clinical studies using this approach have yielded only modest clinical benefit, with often significant toxicity and practical limitations. Therefore, there are currently no anti-hypoxia treatments in widespread clinical use. As an emerging alternative strategy, we discuss the relevance of inhibiting tumour oxygen metabolism to alleviate hypoxia and highlight recently initiated clinical trials using this approach. PMID: 29436847 [PubMed - as supplied by publisher]
Source: The British Journal of Radiology - Category: Radiology Authors: Tags: Br J Radiol Source Type: research