Dysfunctional Limbic Circuitry Underlying Freezing of Gait in Parkinson ’s Disease

This study provides the first evidence that dysfunctional fronto-striato-limbic processes may underpin the link between anxiety and FOG in PD. It is proposed that freezers have heightened striato-limbic load and reduced top-down attentional control at rest, which when further challenged by the parallel processing demands of walking may precipitate FOG.
Source: Neuroscience - Category: Neuroscience Source Type: research