Motor unit number index and neurophysiological index as candidate biomarkers of presymptomatic motor neuron loss in amyotrophic lateral sclerosis

Discussion: Mean‐MUNIX and NI were more sensitive than clinical measures at detecting LMN loss in presymptomatic limbs from patients with slowly progressive ALS. Therefore, these electrophysiological biomarkers should be included in early study phases as meaningful outcome measures. Muscle Nerve, 2018

http://onlinelibrary.wiley.com/resolve/doi?DOI=10.1002%2Fmus.26087

Source: Muscle and Nerve - February 12, 2018 Category: Internal Medicine Authors: Marcio Luiz Escorcio ‐Bezerra, Agessandro Abrahao, Karlo Faria Nunes, Nadia Iandoli De Oliveira Braga, Acary Souza Bulle Oliveira, Lorne Zinman, Gilberto Mastrocola Manzano Tags: Clinical Research Article Source Type: research