Involvement of Ventral Periaqueductal Gray Dopaminergic Neurons in Propofol Anesthesia.

Involvement of Ventral Periaqueductal Gray Dopaminergic Neurons in Propofol Anesthesia. Neurochem Res. 2018 Feb 07;: Authors: Li J, Yu T, Shi F, Zhang Y, Duan Z, Fu B, Zhang Y Abstract It has been reported that central dopaminergic system is implicated in the mechanism underlying general anesthesia. Whether dopamine (DA) neurons in midbrain ventral periaqueductal gray (vPAG) are involved in general anesthesia and how general anesthetics affect these neurons remain sparsely documented. To determine the role of vPAG DA neurons in propofol-induced anesthesia, we performed microinjection of 6-hydroxydopamine (6-OHDA) into vPAG to damage DA neurons and investigated the alteration in somatosensory electroencephalogram (EEG), as well as the induction and recovery time of propofol anesthesia. Subsequently, we examined the effect of propofol on the electrophysiological activity of DA neurons in vPAG using whole-cell patch clamp. Two weeks after 6-OHDA microinfusion, DA neurons in the vPAG were markedly reduced by 63.6% in the 6-OHDA-treated rats compared with vehicle rats. This lesion significantly shortened the induction time (7.15 ± 3.97 s vs. 11.18 ± 2.83 s, P 
Source: Neurochemical Research - Category: Neuroscience Authors: Tags: Neurochem Res Source Type: research

Related Links:

A new study investigates whether the association between intraoperative hypotension and post-surgical acute kidney injury varies by patient and procedure preoperative risk.Anesthesiology
Source: Medscape Today Headlines - Category: Consumer Health News Tags: Anesthesiology Journal Article Source Type: news
From A to Z-Packs: Antibiotics and anesthetics especially threatened as up to 90% of their ingredients come from China.
Source: Health News: CBSNews.com - Category: Consumer Health News Source Type: news
INTRODUCTION: Blast-induced mild traumatic brain injury was generated in a mouse model using a shock tube to investigate recovery and axonal injury from single blast. METHODS: A supersonic helium wave hit the head of anesthetized male young adult m...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Economics of Injury and Safety, PTSD, Injury Outcomes Source Type: news
Critically ill patients with acute respiratory or cardiopulmonary failure who are on long-term mechanical ventilation too often suffer a variety of side effects. These can include ventilator associated lung injury, pneumonia, and diaphragm dysfunctio...
Source: Medgadget - Category: Medical Devices Authors: Tags: Anesthesiology Cardiac Surgery Cardiology Critical Care Pediatrics Source Type: blogs
Conditions:   Postoperative Pain;   Analgesia;   Local Anaesthetic;   Abdominal Injury Interventions:   Procedure: fascial block as postoperative analgesia;   Drug: Morphine;   Device: PCA CADD Smith Medical pumps Sponsor:   Hospital Medina del Campo Completed
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
This study compared the hemodynamics and perioperative outcomes of commonly used modalities.BMC Anesthesiology
Source: Medscape Critical Care Headlines - Category: Intensive Care Tags: Anesthesiology Journal Article Source Type: news
The Journal of Physical Chemistry BDOI: 10.1021/acs.jpcb.9b11756
Source: Journal of Physical Chemistry B - Category: Chemistry Authors: Source Type: research
This quality improvement (QI) project was performed at a single center to determine the incidence of postoperative complications associated with use of cuffed airway devices. An educational program was then co...
Source: BMC Anesthesiology - Category: Anesthesiology Authors: Tags: Research article Source Type: research
Gingival lesions rarely occur in newborns. However, when present, they commonly worry the parents and impair the infant's feeding, thus affecting growth. Such lesions are usually nonneoplastic in nature, although malignancies may develop; therefore, specimens must be submitted for histopathologic examination. A 2-month-old girl presented with a 10-mm nodule on the anterior lower alveolar ridge in association with natal tooth extraction and neonatal tooth eruption. The lesion was excised with high-power laser under local anesthesia, and a histopathologic diagnosis of a peripheral ossifying fibroma was made.
Source: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics - Category: ENT & OMF Authors: Tags: Case Report Source Type: research
Each year around 66,000 people in England, Wales and Northern Ireland will suffer a hip fracture [1], making this the commonest reason for an older person to need emergency anaesthesia and surgery and is the commonest cause of accidental death.
Source: Injury - Category: Orthopaedics Authors: Source Type: research
More News: Anesthesia | Anesthesiology | Brain | Diprivan | Neurology | Neuroscience | Propofol