The Diuretic Potential of Sacubitril/Valsartan: A Tale of 2 Patients

Conclusions: After titration to target-dose ARNi therapy, both patients demonstrated improved fluid and electrolyte balance, as well as a reduction in diuretic therapy requirements, suggesting a mechanism of diuresis attributable to ARNi therapy. Clinical Implications: Angiotensin receptor–neprilysin inhibitor therapy seems to promote a clinically relevant diuresis in heart failure patients because of increased levels of functioning natriuretic peptides. Awareness of this diuretic potential may allow for optimization of heart failure regimens with pharmacologic agents demonstrated to improve morbidity and mortality, while preventing adverse effects that may occur with overdiuresis.
Source: Journal of Cardiovascular Nursing - Category: Nursing Tags: DEPARTMENTS: Pharmacology: Evidence Meets Practice Source Type: research