Drug targeting of one or more aminoacyl-tRNA synthetase in the malarial parasite Plasmodium falciparum.

Drug targeting of one or more aminoacyl-tRNA synthetase in the malarial parasite Plasmodium falciparum.
Drug Discov Today. 2018 Feb 02;:
Authors: Yogavel M, Chaturvedi R, Babbar P, Malhotra N, Jain V, Sharma A
Abstract
Malaria remains a major infectious disease and, despite incidence reduction, it threatens resurgence in drug-resistant forms. Antimalarial drugs remain the mainstay of therapeutic options and hence there is a constant need to identify and validate new druggable targets. Plasmodium falciparum aminoacyl-tRNA synthetases (Pf-aaRSs) drive protein translation and are potent targets for development of next-generation antimalarials. Here, we detail advances made in structural-biology-based investigations in Pf-aaRSs and discuss their distribution of druggable pockets. This review establishes a platform for systematic experimental dissection of malarial parasite aaRSs as a new focus for sustained drug development efforts against malaria.
PMID: 29408369 [PubMed - as supplied by publisher]

Source: Drug Discovery Today - February 2, 2018 Category: Drugs & Pharmacology Authors: Yogavel M, Chaturvedi R, Babbar P, Malhotra N, Jain V, Sharma A Tags: Drug Discov Today Source Type: research