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Deep brain stimulation -- A new treatment approach in patients with multiple sclerosis

(Charit é - Universit ä tsmedizin Berlin) A pilot study conducted by researchers from Charit é 's NeuroCure Cluster of Excellence has shown that treatment with deep transcranial magnetic stimulation (dTMS) significantly reduces symptoms of fatigue in patients with multiple sclerosis (MS). Published in the current issue of the journal Neurology: Neuroimmunology&Neuroinflammation*, results from this research suggest that TMS is a safe option for the treatment of patients with MS.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news

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The latest in neuroscience—sorted and summarized for you Welcome to The Neuroscience Report where each week we will highlight a specific topic in neuroscience and provide you with links to 5 journal articles, 5 news articles, and 5 wildcard picks. Brought to you by Innovations in Clinical Neuroscience—your source for peer-reviewed, evidence-based information. This week’s topic: Advances in Neuroscience 5 Journal Articles Closing the loop on impulsivity via nucleus accumbens delta-band activity in mice and man   Can surgical simulation be used to train detection and classification of neu...
Source: Innovations in Clinical Neuroscience - Category: Neuroscience Authors: Tags: The Neuroscience Report Source Type: research
Aim: Tremor is common in multiple sclerosis (MS) and often affects quality of life. Medical management is largely unsatisfactory, however, functional neurosurgical techniques including deep brain stimulation (DBS) and thalamotomy have shown promise. This literature review sought to evaluate the efficacy and safety of functional neurosurgery for MS tremor.
Source: International Journal of Surgery - Category: Surgery Authors: Source Type: research
PremiseTrigeminal neuralgia is a severe facial pain disorder that has been studied for decades. Classical trigeminal neuralgia (CTN) is either idiopathic or caused by neurovascular compression. The related painful trigeminal neuropathies are often secondary to other causes, such as multiple sclerosis or trauma. ProblemTherapies for trigeminal neuralgia and neuropathy have often been pharmacologic or surgical. Pharmacologic therapies are not effective in some cases and often cause side effects, some substantial. Surgery can have comorbidity (such as anesthesia dolorosa, or painful differentiation of the affected nerve distr...
Source: Headache: The Journal of Head and Face Pain - Category: Neurology Authors: Tags: Headache Currents Source Type: research
Abstract PREMISE: Trigeminal neuralgia is a severe facial pain disorder that has been studied for decades. Classical trigeminal neuralgia (CTN) is either idiopathic or caused by neurovascular compression. The related painful trigeminal neuropathies are often secondary to other causes, such as multiple sclerosis or trauma. PROBLEM: Therapies for trigeminal neuralgia and neuropathy have often been pharmacologic or surgical. Pharmacologic therapies are not effective in some cases and often cause side effects, some substantial. Surgery can have comorbidity (such as anesthesia dolorosa, or painful differentiation ...
Source: Headache - Category: Neurology Authors: Tags: Headache Source Type: research
Publication date: Available online 20 June 2017 Source:The Lancet Neurology Author(s): Seth F Oliveria, Ramon L Rodriguez, Dawn Bowers, Daniel Kantor, Justin D Hilliard, Erin H Monari, Bonnie M Scott, Michael S Okun, Kelly D Foote Background Efficacy in previous studies of surgical treatments of refractory multiple sclerosis tremor using lesioning or deep brain stimulation (DBS) has been variable. The aim of this study was to investigate the safety and efficacy of dual-lead thalamic DBS (one targeting the ventralis intermedius–ventralis oralis posterior nucleus border [the VIM lead] and one targeting the ventralis o...
Source: The Lancet Neurology - Category: Neurology Source Type: research
Tremor is the most common disorder in patients with multiple sclerosis and greatly contributes to the disability of these patients. This tremor rarely presents with the high-frequency action component seen in primary tremor disorders; rather, it is the combination of several features, particularly cerebellar ones. Therefore, drugs are rarely effective, whereas surgery can provide variable results depending on the severity of the underlying ataxia. In The Lancet Neurology, Seth Oliveria and colleagues1 report the findings from their single centre, single-blind, prospective, randomised pilot trial of dual-lead thalamic deep ...
Source: Lancet Neurology - Category: Neurology Authors: Tags: Comment Source Type: research
Dual lead thalamic DBS might be a safe and effective option for improving severe, refractory multiple sclerosis tremor. Larger studies are necessary to show whether this technique is widely applicable, safe in the long-term, and effective in treating multiple sclerosis tremor or other severe tremor disorders.
Source: Lancet Neurology - Category: Neurology Authors: Tags: Articles Source Type: research
CONCLUSIONS Staged bilateral GKT provided effective relief for medically refractory, disabling, bilateral tremor without increased risk of neurological complications. It is an appropriate strategy for carefully selected patients with medically refractory bilateral tremor who are not eligible for deep brain stimulation. PMID: 28387629 [PubMed - as supplied by publisher]
Source: Journal of Neurosurgery - Category: Neurosurgery Authors: Tags: J Neurosurg Source Type: research
The effect of deep brain stimulation (DBS) on phonatory behavior and voice quality in eight patients with multiple sclerosis (MS) was examined instrumentally and perceptually. The acoustic signals of vowel productions obtained from patients (produced with and without stimulation) and from a group of 16 healthy control speakers were analyzed to prove statistically the changes of phonatory behavior and voice quality.
Source: Journal of Voice - Category: ENT & OMF Authors: Source Type: research
Quantitative susceptibility mapping (QSM) is an MR technique that depicts and quantifies magnetic susceptibility sources. Mapping iron, the dominant susceptibility source in the brain, has many important clinical applications. Herein, we review QSM applications in the diagnosis, medical management, and surgical treatment of disease. To assist in early disease diagnosis, QSM can identify elevated iron levels in the motor cortex of amyotrophic lateral sclerosis patients, in the substantia nigra of Parkinson's disease (PD) patients, in the globus pallidus, putamen, and caudate of Huntington's disease patients, and in the basa...
Source: NMR in Biomedicine - Category: Radiology Authors: Tags: Special issue review article Source Type: research
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