Deep brain stimulation -- A new treatment approach in patients with multiple sclerosis

(Charit é - Universit ä tsmedizin Berlin) A pilot study conducted by researchers from Charit é 's NeuroCure Cluster of Excellence has shown that treatment with deep transcranial magnetic stimulation (dTMS) significantly reduces symptoms of fatigue in patients with multiple sclerosis (MS). Published in the current issue of the journal Neurology: Neuroimmunology&Neuroinflammation*, results from this research suggest that TMS is a safe option for the treatment of patients with MS.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news

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Tremor in Multiple Sclerosis is an important cause for disability. As medical treatment often does not provide a sufficient reduction of tremor amplitude, deep brain stimulation is an important option in these patients. Because in previous studies often unilateral stimulation of the VIM was performed, the aim of our retrospective analysis was to evaluate the effect of bilateral stimulation on tremor amplitude, activities of daily living, and due to an additional effect on axial tremor, improvement of global disability (EDSS) and mobility.
Source: Clinical Neurophysiology - Category: Neuroscience Authors: Source Type: research
When it came to getting the best treatment for his parents ’ neurologic illnesses, Sam Miller and his family experienced frustration finding the right doctors in their home country of South Africa.Miller ’s mother, Brenda, developed multiple sclerosis in her late 20s, and his father, Winston, was diagnosed with Parkinson’s disease in his 60s.Over the four decades of his mother ’s illness before her death in 2008, the increasingly acute shortage of neurologists in South Africa made the top specialists there much sought-after and overworked. They had little time to talk through treatment options, much...
Source: UCLA Newsroom: Health Sciences - Category: Universities & Medical Training Source Type: news
The treatment of medically refractory tremor has evolved over the past half-century from intraoperative thalamotomy to deep brain stimulation (DBS) of the thalamic ventral intermediate nucleus (VIM). VIM DBS has proven efficacious for patients with essential tremor (ET), tremor-dominant Parkinson ’s disease (PD), and less common causes of tremor including multiple sclerosis and orthostatic tremor. Within the past 15 years, unilateral radiosurgical VIM thalamotomy has emerged as a comparably efficacious treatment modality, particularly for ET and tremor-dominant PD patients.
Source: International Journal of Radiation Oncology * Biology * Physics - Category: Radiology Authors: Tags: Poster Abstract Source Type: research
ConclusionsDBS of select targets may represent an effective therapeutic strategy for uncommon tremor disorders, although the level of evidence is currently in its incipient form and based on single cases or limited case series. An international registry is, therefore, warranted to clarify selection criteria, long-term results, and optimal surgical targets.
Source: Journal of Neurology - Category: Neurology Source Type: research
CONCLUSIONS SRS to the unilateral thalamic ventral intermediate nucleus, with a dose of 130-150 Gy, is a well-tolerated and effective treatment for reducing medically refractory tremor, and one that is recommended by the International Stereotactic Radiosurgery Society. PMID: 29473775 [PubMed - as supplied by publisher]
Source: Journal of Neurosurgery - Category: Neurosurgery Authors: Tags: J Neurosurg Source Type: research
The latest in neuroscience—sorted and summarized for you Welcome to The Neuroscience Report where each week we will highlight a specific topic in neuroscience and provide you with links to 5 journal articles, 5 news articles, and 5 wildcard picks. Brought to you by Innovations in Clinical Neuroscience—your source for peer-reviewed, evidence-based information. This week’s topic: Advances in Neuroscience 5 Journal Articles Closing the loop on impulsivity via nucleus accumbens delta-band activity in mice and man   Can surgical simulation be used to train detection and classification of neu...
Source: Innovations in Clinical Neuroscience - Category: Neuroscience Authors: Tags: The Neuroscience Report Source Type: research
Aim: Tremor is common in multiple sclerosis (MS) and often affects quality of life. Medical management is largely unsatisfactory, however, functional neurosurgical techniques including deep brain stimulation (DBS) and thalamotomy have shown promise. This literature review sought to evaluate the efficacy and safety of functional neurosurgery for MS tremor.
Source: International Journal of Surgery - Category: Surgery Authors: Source Type: research
PremiseTrigeminal neuralgia is a severe facial pain disorder that has been studied for decades. Classical trigeminal neuralgia (CTN) is either idiopathic or caused by neurovascular compression. The related painful trigeminal neuropathies are often secondary to other causes, such as multiple sclerosis or trauma. ProblemTherapies for trigeminal neuralgia and neuropathy have often been pharmacologic or surgical. Pharmacologic therapies are not effective in some cases and often cause side effects, some substantial. Surgery can have comorbidity (such as anesthesia dolorosa, or painful differentiation of the affected nerve distr...
Source: Headache: The Journal of Head and Face Pain - Category: Neurology Authors: Tags: Headache Currents Source Type: research
Abstract PREMISE: Trigeminal neuralgia is a severe facial pain disorder that has been studied for decades. Classical trigeminal neuralgia (CTN) is either idiopathic or caused by neurovascular compression. The related painful trigeminal neuropathies are often secondary to other causes, such as multiple sclerosis or trauma. PROBLEM: Therapies for trigeminal neuralgia and neuropathy have often been pharmacologic or surgical. Pharmacologic therapies are not effective in some cases and often cause side effects, some substantial. Surgery can have comorbidity (such as anesthesia dolorosa, or painful differentiation ...
Source: Headache - Category: Neurology Authors: Tags: Headache Source Type: research
Publication date: Available online 20 June 2017 Source:The Lancet Neurology Author(s): Seth F Oliveria, Ramon L Rodriguez, Dawn Bowers, Daniel Kantor, Justin D Hilliard, Erin H Monari, Bonnie M Scott, Michael S Okun, Kelly D Foote Background Efficacy in previous studies of surgical treatments of refractory multiple sclerosis tremor using lesioning or deep brain stimulation (DBS) has been variable. The aim of this study was to investigate the safety and efficacy of dual-lead thalamic DBS (one targeting the ventralis intermedius–ventralis oralis posterior nucleus border [the VIM lead] and one targeting the ventralis o...
Source: The Lancet Neurology - Category: Neurology Source Type: research
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