Polygenic risk for schizophrenia affects working memory and its neural correlates in healthy subjects

Schizophrenia is a disorder with a high heritability. Patients as well as their first degree relatives display lower levels of performance in a number of cognitive domains compared to subjects without genetic risk. Several studies could link these aberrations to single genetic variants, however, only recently, polygenic risk scores as proxies for genetic risk have been associated with cognitive domains and their neural correlates.In the present study, a sample of healthy subjects (n=137) performed a letter version of the n-back task while scanned with 3-T fMRI.

Source: Schizophrenia Research - February 4, 2018 Category: Psychiatry Authors: Axel Krug, Bruno Dietsche, Rebecca Z öllner, Dilara Yüksel, Markus M. Nöthen, Andreas J. Forstner, Marcella Rietschel, Udo Dannlowski, Bernhard T. Baune, Robert Maier, Stephanie H. Witt, Tilo Kircher Source Type: research