Cross-Reactivity and Tolerability Of Cephalosporins In Patients With Ige-Mediated Hypersensitivity To Penicillins

Conclusions Cross-reactivity between penicillins and cephalosporins seems to be mainly related to side chain similarity or identity.Subjects with an IgE-mediated hypersensitivity to penicillins could be treated with cephalosporins like cefuroxime and ceftriaxone that have side chain determinants different from those of penicillins and are negative in pretreatment skin testing.
Source: The Journal of Allergy and Clinical Immunology: In Practice - Category: Allergy & Immunology Source Type: research