Hypoglossal Nerve Stimulation in a Pre-Clinical Anesthetized Rabbit Model Relevant to OSA

Publication date: Available online 2 February 2018 Source:Respiratory Physiology & Neurobiology Author(s): Girriso F. Benderro, Jenniffer Gamble, Matthew A. Schiefer, Jonathan Z. Baskin, Yeritza Hernandez, Kingman P. Strohl We tested the functional effects of hypoglossal (CNXII) stimulation in the anesthetized rabbit before and after injections of saline into the tongue base to obstruct the airway. Data (n = 6) show little or no effect of CN XII trunk stimulation; however, medial branch stimulation (20–100 Hz; 50–500 μs pulse width, and incremental increases from 10 μA) reduced upper airway resistance. Medial branch stimulation was less effective in reducing resistance than anterior advancement of the hyoid. Endoscopic viewing (n-3) of the retropalate showed this region as the narrowest and dynamically changed by anterior hyoid displacement, with less evident effects than CNXII stimulation. We conclude that under these conditions CNXII medial branch stimulation reduces airway resistance, especially after induced obstruction.
Source: Respiratory Physiology and Neurobiology - Category: Respiratory Medicine Source Type: research