Mfn2 ablation causes an oxidative stress response and eventual neuronal death in the hippocampus and cortex

Mitochondria are the organelles responsible for energy metabolism and have a direct impact on neuronal function and survival. Mitochondrial abnormalities have been well characterized in Alzheimer Disease (AD)....

Source: Molecular Neurodegeneration - February 1, 2018 Category: Neurology Authors: Sirui Jiang, Priya Nandy, Wenzhang Wang, Xiaopin Ma, Jeffrey Hsia, Chunyu Wang, Zhenlian Wang, Mengyue Niu, Sandra L. Siedlak, Sandy Torres, Hisashi Fujioka, Ying Xu, Hyoung-gon Lee, George Perry, Jun Liu and Xiongwei Zhu Tags: Research article Source Type: research