Acquired Amegakaryocytic Thrombocytopenia and Red Cell Aplasia in a Patient with Thymoma Progressing to Aplastic Anemia Successfully Treated with Allogenic Stem Cell Transplantation

We report a patient with thymoma complicated by pure red cell aplasia (PRCA) and AAMT who progressed to develop aplastic anemia (AA). The patient was refractory to 10-months of immunosuppressive therapy with cyclosporine, prednisone, and antithymocyte globulin. She was eventually treated with allogeneic stem cell transplantation (allo-SCT). On Day +323 the patient continues to be transfusion-independent. This case illustrates how in patients with thymoma and AAMT may herald development of AA. This is also the first report of a patient with AAMT progressing to thymoma-associated AA being successfully treated with allo-SCT. The successful outcome suggests allo-SCT as a feasible option similar to other AA patients.
Source: Hematology Oncology and Stem Cell Therapy - Category: Cancer & Oncology Source Type: research