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Gabapentin in mixed drug fatalities: does this frequent analyte deserve more attention? - Finlayson G, Chavarria M, Chang S, Gardner T, Grande A, MacCallum C, DeJong JL, Quesnelle K.

From 2000 to 2014, drug overdose deaths increased 137% in the United States, and 61% of these deaths included some form of opiate. The vast majority of opiate-related drug fatalities include multiple drugs, although there is scant data quantitatively descr...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Alcohol and Other Drugs Source Type: news

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The objective of this study is to determine whether concomitant benzodiazepine-opioid use increases the incidence of adverse outcomes above the baseline risk of nonacute opioid-only use. The dataset contained all veterans who filled at least 1 opioid prescription during the years 2008 to 2012. Nonacute opioid use was defined as having opioid prescriptions greater than or equal to 20 days within a 60-day period. Concomitant use was defined as having opioid and benzodiazepine prescriptions that overlapped for at least 7 days. Nonacute opioid-only users were matched to concomitant opioid-benzodiazepine users based on propensi...
Source: Pain - Category: Anesthesiology Tags: Research Paper Source Type: research
Background Reports indicate a geographic effect of socioeconomic inequalities on the occurrence of opioid-related fatal overdoses. We aim to (1) estimate the rates of opioid-related overdoses, (2) estimate the association of benzodiazepine co-ingestion wit...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Alcohol and Other Drugs Source Type: news
ConclusionsTHN programs are effective in improving knowledge related to overdose response. Major improvements in knowledge were limited to overdose recognition and effect of naloxone suggesting that education may best be focused on overdose signs and the use of naloxone among populations accessed through these programs. A focus on younger people also appears warranted. Further work is needed to understand the impact of training and knowledge on actual behaviours around overdose events.
Source: Drug and Alcohol Review - Category: Addiction Authors: Tags: Original Paper Source Type: research
In the United States, prescription opioid misuse (POM) is a severe threat to public health. Compared to other prescription drugs, POM has the highest prevalence of use and is only second to marijuana in terms of overall illicit drug use (CBHSQ, 2016a; Miech et al., 2017). Roughly one-third of all overdose deaths in 2015 were attributable to prescription opioids, and the number of overdose deaths associated with opioids has nearly doubled since 2002 (Hedegaard et al., 2017). Because of this, much research attention has focused on POM, but notable gaps in the literature remain.
Source: Drug and Alcohol Dependence - Category: Addiction Authors: Tags: Short communication Source Type: research
Source: Drug and Alcohol Dependence - Category: Addiction Authors: Tags: Full length article Source Type: research
BACKGROUND: Opioid overdose is a major and increasing cause of injury and death. There is an urgent need for interventions to reduce overdose events among high-risk persons. METHODS: Adults at elevated risk for opioid overdose involving heroin or p...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Alcohol and Other Drugs Source Type: news
This report describes 4 cases of deaths associated with brotizolam poisoning from a single drug overdose. The ages ranged from 51 to 90 years, and the postmortem interval between death and tissue sampling was 1.5 to 2.5 days. These deaths were classified as 1 homicide and 3 suicides. The concentration of the brotizolam ranged from 0.05 to 0.21 mg/L in the blood samples. Ethanol, which could cause mild alcohol intoxication, was detected in the blood samples from 2 cases. Postmortem examinations did not find any significant pathologic conditions, except for a case of death by drowning in a bathtub due to brotizolam poisoning...
Source: The American Journal of Forensic Medicine and Pathology - Category: Forensic Medicine Tags: Case Reports Source Type: research
Acetaminophen (APAP) is the leading cause of acute liver failure (ALF), although the worldwide frequency is variable. APAP hepatotoxicity develops either following intentional overdose or unintentional ingestion (therapeutic misadventure) in the background of several factors, such as concomitant use of alcohol and certain medications that facilitate the formation of reactive and toxic metabolites. Spontaneous survival is more common in APAP-induced ALF compared with non-APAP etiologies. N-acetylcysteine is recommended for all patients with APAP-induced ALF and it reduces mortality. Liver transplantation should be offered e...
Source: Clinics in Liver Disease - Category: Gastroenterology Authors: Source Type: research
Source: Drug and Alcohol Dependence - Category: Addiction Authors: Tags: Short communication Source Type: research
U.S. life expectancy has decreased for the second year in a row, and an editorial in the BMJ points to three contributing factors: drugs, alcohol and suicides, particularly among middle-age white Americans and those living in rural communities. The authors of the paper paint a bleak picture of the problems facing much of the United States today, but the authors say that policies that bolster the middle-class can help reverse the trend. The recent drop in life expectancy is alarming, the editorial states, “because life expectancy has risen for much of the past century in developed countries, including in the U.S.&rdqu...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized healthytime onetime public health Source Type: news
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