Blockade of dopamine D2 receptors disrupts intrahippocampal connectivity and enhances pain ‐related working memory deficits in neuropathic pain rats

ConclusionsTogether, these results suggest that disruption of the dopaminergic balance in the intrahippocampal networks may be important for the development of cognitive deficits experienced during painful conditions. SignificanceThis study provides new insights into the role of D2r in the manifestation of pain‐related sWM deficits. Our findings support that selective blockade of D2r produces a significant decrease in intrahippocampal connectivity mediated by theta‐oscillations, and amplifies pain‐related sWM deficits. These results suggest that further characterization of intrahippocampal dopaminergic modulation may be clinically relevant for the understanding of cognitive impairments that accompanies nociceptive stressful conditions.
Source: European Journal of Pain - Category: Anesthesiology Authors: Tags: Original Article Source Type: research