Tacrolimus-induced nephrotoxicity in mice is associated with microRNA deregulation.

In conclusion, this study suggests for the first time that miRNAs, especially fibromiRs, participate to Tacrolimus-induced nephrotoxic effects. Therefore, targeting miRNAs may be a new therapeutic option to counteract Tacrolimus deleterious effects on kidney.
PMID: 29362864 [PubMed - as supplied by publisher]

Source: Archives of Toxicology - January 23, 2018 Category: Toxicology Authors: Vandenbussche C, Van der Hauwaert C, Dewaeles E, Franczak J, Hennino MF, Gnemmi V, Savary G, Tavernier Q, Nottet N, Paquet A, Perrais M, Blum D, Mari B, Pottier N, Glowacki F, Cauffiez C Tags: Arch Toxicol Source Type: research