Tamoxifen attenuates development of lithium-induced nephrogenic diabetes insipidus in rats.

In conclusion, TAM attenuated dose-dependently polyuria, impaired urine concentration, and downregulation of AQP2 protein expression in rats with lithium-induced NDI. These findings suggest that TAM is likely to be a novel therapeutic option for lithium-induced NDI. PMID: 29357422 [PubMed - as supplied by publisher]
Source: American Journal of Physiology. Renal Physiology - Category: Physiology Authors: Tags: Am J Physiol Renal Physiol Source Type: research