Tamoxifen attenuates development of lithium-induced nephrogenic diabetes insipidus in rats.
In conclusion, TAM attenuated dose-dependently polyuria, impaired urine concentration, and downregulation of AQP2 protein expression in rats with lithium-induced NDI. These findings suggest that TAM is likely to be a novel therapeutic option for lithium-induced NDI.
PMID: 29357422 [PubMed - as supplied by publisher]
Source: American Journal of Physiology. Renal Physiology - Category: Physiology Authors: Tingskov SJ, Hu S, Frøkiær J, Kwon TH, Wang W, Norregaard R Tags: Am J Physiol Renal Physiol Source Type: research
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