Association of depression with evolution of heart failure in patients with type 2 diabetes mellitus

Depression is a prevalent, independent predictor of mortality in patients with heart failure (HF). Depression is also common in type 2 diabetes mellitus (T2DM), which is itself an important risk factor for HF....
Source: Cardiovascular Diabetology - Category: Cardiology Authors: Tags: Original investigation Source Type: research

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In this study, LC/NE neurons were pre-lesioned by N-(2-chloroethyl)-N-ethyl-2-bromobenzylamine (DSP-4) in paraquat and maneb-induced mouse PD model. We found that DSP-4 significantly impaired learning and memory performance in paraquat and maneb-treated mice, although it failed to interfere with constipation and depression-like behaviors. Consistently, DSP-4 treatment increased hippocampal neurodegeneration, synaptic loss, α-synuclein expression and Ser129-phosphorylation in mice treated with these two pesticides. Mechanistically, DSP-4 increased iron content in hippocampus by disrupting the balance of iron release p...
Source: Neuroscience - Category: Neuroscience Source Type: research
Publication date: November 2019Source: Infant Behavior and Development, Volume 57Author(s): Stephanie H. Parade, Kristyn Wong, Renee Belair, Susan Dickstein, Ronald SeiferAbstractObserved infant temperamental difficulty and infant sleep efficiency and sleep variability were examined as predictors of maternal depressive symptoms, maternal sensitivity, and family functioning. Eight observations at 8-months postpartum were used to assess infant temperament, and actigraphy was used to measure infant sleep for 1-week at the time of the 8-month assessment. Structured clinical interviews were used to assess maternal depressive sy...
Source: Infant Behavior and Development - Category: Child Development Source Type: research
Publication date: Available online 15 October 2019Source: Food Research InternationalAuthor(s): Mohammed Bule, Shekoufeh Nikfar, Mohsen Amini, Mohammad AbdollahiAbstractThymoquinone (2-isopropyl-5-methylbenzo-1, 4-quinone) (TQ) is a quinone derivative with a yellow crystalline appearance, abundantly found in black cumin, Nigella sativa L. TQ has diverse pharmacological properties. The aim of this systematic review on the antidiabetic effects of TQ is to evaluate the currently available evidence and conduct meta-analysis. A literature search of articles published until 25 January 2019 was done on PubMed, EMBASE, Web of Scie...
Source: Food Research International - Category: Food Science Source Type: research
Publication date: Available online 9 October 2019Source: Food Research InternationalAuthor(s): Dave Jaydeep Pinakin, Vikas Kumar, Sheenam Suri, Rakesh Sharma, Manisha KaushalAbstractA numerous types of tree flowers are present in nature and few of them such as Rhdodendron, Bauhinia, Mahua, Gulmohar, Palash, Sesbania, Woodfordia, Simbal, etc. are being utilized traditionally as food and medicine by the localities of India. These flowers are rich in phytochemical (flavonoids, anthocyanins, phenolic acids, carotenoids, tannins, saponins) and possessing numerous health benefits (antioxidant activity, anti-inflammation, anti-ca...
Source: Food Research International - Category: Food Science Source Type: research
ConclusionsPractices to improve provider coordination within and across primary care and specialty care services may improve patient experiences of care coordination. Improvements in these areas may improve care efficiency and effectiveness.
Source: Journal of General Internal Medicine - Category: Internal Medicine Source Type: research
ConclusionsResults suggest that VA may be adequately addressing coordination needs related to cardiovascular conditions, but more attention could be placed on coordination for mental health conditions. While specialized programs for more severe conditions (e.g., heart failure and serious mental illness) are important, coordination is also needed for more common, less severe conditions (e.g., hypertension, depression, anxiety). Strengthening coordination for common, less severe conditions is particularly important as VA develops alternative models (e.g., community care) that may negatively impact the degree to which care is coordinated.
Source: Journal of General Internal Medicine - Category: Internal Medicine Source Type: research
In conclusion, the impaired in situ activity of RyR2 may also account for the poor overall cardiac outcome reported in MetS patients; hence, the SERCA pump and RyR2 are both attractive potential targets for future therapies. Introduction Metabolic syndrome (MetS) is a cluster of biochemical and physiological risk factors for cardiovascular disease and diabetes mellitus type 2 (DM2); it represents a severe public health problem around the world (Alberti et al., 2009). Risk factors for MetS include obesity (particularly central obesity), elevated triglyceride (TG) levels, low high-density lipoprotein cholesterol (HDL...
Source: Frontiers in Physiology - Category: Physiology Source Type: research
Fight Aging! provides a weekly digest of news and commentary for thousands of subscribers interested in the latest longevity science: progress towards the medical control of aging in order to prevent age-related frailty, suffering, and disease, as well as improvements in the present understanding of what works and what doesn't work when it comes to extending healthy life. Expect to see summaries of recent advances in medical research, news from the scientific community, advocacy and fundraising initiatives to help speed work on the repair and reversal of aging, links to online resources, and much more. This content is...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
Obstructive sleep apnea (OSA) is characterized by repetitive pharyngeal collapse during sleep. The result is fragmented sleep, excessive daytime sleepiness; hypoxia and hypercarbia; decreased vigilance, motor coordination, and executive function; depression; and decreased quality of life. If untreated, the patient can develop hypertension, arrhythmias, congestive heart failure, a higher risk for cardiovascular events, and type 2 diabetes mellitus. Both stroke and all-cause mortality are both increased as OSA increases in severity.
Source: Dental Abstracts - Category: Dentistry Tags: Inquiry Source Type: research
In conclusion, we found that IS status was associated with a significant increase in Hannum DNA methylation, likely as a consequence of the accumulation of cardiovascular risk factors, and near signification with Horvath method. Patients with IS were biologically older than controls, a difference that was more obvious in young stroke. This could open up the possibility of useful new biomarker of stroke risk. Latest Headlines from Fight Aging! A Profile of Kelsey Moody and Ichor Therapeutics https://www.fightaging.org/archives/2016/09/a-profile-of-kelsey-moody
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
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