Ultrasound-Mediated Microbubble Destruction Suppresses Melanoma Tumor Growth

In this study, we investigated a novel treatment approach, the use of low-intensity ultrasound (2.3 W/cm2 at 1  MHz)-mediated Optison microbubble (MB) destruction (UMMD) to treat melanoma in a flank tumor model. The effect of UMMD was first evaluated in the melanoma cell line B16 F10 (B16) in vitro and then in mice inoculated with B16 cells. MB+B16 cells were exposed to US in vitro, resulting in significan t cell death proportional to duty cycle (R2 = 0.74): approximately 30%, 50%, 80% and 80% cell death at 10%, 30%, 50% and 100% DC respectively.

Source: Ultrasound in Medicine and Biology - January 18, 2018 Category: Radiology Authors: Kee W. Jang, Dongrim Seol, Lei Ding, Tae-Hong Lim, Joseph A. Frank, James A. Martin Tags: Original Contribution Source Type: research