Bridging the molecular divide: Alcohol ‐induced downregulation of PAX9 and tumour development

Abstract The pathogenesis of oro‐esophaeal squamous cell carcinoma is causally linked to the consumption of alcohol. Beyond the carcinogenic effects of ethanol and its metabolites via DNA damage, the precise mechanisms by which alcohol drives tumorigenesis remain to be fully elucidated. A novel contributor now revealed is aberrant differentiation and proliferation mediated by suppression of PAX9, a key regulator of normal squamous maturation in oro‐esophageal tissues.
Source: The Journal of Pathology - Category: Pathology Authors: Tags: Invited Commentary Source Type: research