Near-Infrared Spectroscopy and Vascular Occlusion Test for Predicting Clinical Outcome in Pediatric Cardiac Patients: A Prospective Observational Study

This study is designed to determine the feasibility and utility of vascular occlusion test variables as measured by INVOS (Medtronic, Dublin, Ireland) in pediatric cardiac patients. Design: A prospective observational study. Setting: A tertiary children’s hospital. Patients: Children less than or equal to 8 years old who were scheduled for elective cardiac surgery under cardiopulmonary bypass. Interventions: A vascular occlusion test (3 min of ischemia and reperfusion) was performed on the calf at three time points: after induction of anesthesia (T0), during cardiopulmonary bypass (T1), and after sternal closure (T2). Measurements and Main Results: Baseline regional tissue hemoglobin oxygen saturation, deoxygenation rate, minimum regional tissue hemoglobin oxygen saturation, and reoxygenation rate were measured using INVOS. Influence of age on variables at each measurement point was also checked using linear regression analysis. Receiver operating characteristics curve analysis was performed to determine the ability of vascular occlusion test variables at T2 to predict the occurrence of major adverse events. Both the deoxygenation and reoxygenation rates were lowest in T1. There was a tendency to decreased regional tissue hemoglobin oxygen saturation in younger patients at T0 (r = 0.37; p
Source: Pediatric Critical Care Medicine - Category: Pediatrics Tags: Cardiac Intensive Care Source Type: research

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In this study, we examined the effect of sevoflurane on the excitatory synaptic transmission at CA1 synapses in hippocampal slices of mice. Sevoflurane at 5% was mixed with 95% O2 and 5% CO2 and bubbled in artificial cerebral spinal fluid (0.69 mM). Extracellular recordings of the field excitatory postsynaptic potential (fEPSP) and presynaptic fiber volley (FV) were made at physiological temperature. In addition, fluorescent measurements of presynaptic Ca2+ transients were performed while simultaneously recording fEPSP. Application of sevoflurane reduced the amplitude of fEPSP (45 ± 8%, n = 5). This effect was accom...
Source: Biomed Res - Category: Research Authors: Tags: Biomed Res Source Type: research
Conditions:   Cesarean Section Complications;   Spinal Anesthetic Toxicity Interventions:   Drug: Norepinephrine 6 mcg;   Drug: Norepinephrine 10 mcg;   Drug: Bupivacaine Hydrochloride;   Drug: Norepinephrine infusion Sponsor:   Cairo University Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Condition:   Anesthesia Intervention:   Procedure: TAP Block Sponsor:   University of Tennessee Completed
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conditions:   Breast Cancer;   Acute Pain;   Anesthesia Interventions:   Procedure: PVB group;   Procedure: MTP block group;   Procedure: Control Group Sponsor:   Ottawa Hospital Research Institute Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conditions:   Anesthesia;   Fluid Responsiveness Intervention:   Diagnostic Test: Fluid bolus Sponsor:   Medical University of Warsaw Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Authors: Soliman LM, Farag E Abstract PMID: 30328338 [PubMed - as supplied by publisher]
Source: Minerva Anestesiologica - Category: Anesthesiology Tags: Minerva Anestesiol Source Type: research
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