Urinary Orosomucoid is Associated with Progressive Chronic Kidney Disease Stage in Patients with Sickle Cell Anemia

Source: American Journal of Hematology - Category: Hematology Authors: Tags: Correspondence Source Type: research

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AbstractDiabetes mellitus (DM) has reached epidemic proportions across the globe with the largest increases seen in sub-Saharan Africa. Those that are diagnosed are largely poorly controlled. This review summarizes the limitations of the use of glycated haemoglobin (HBA1c) in Africa and current knowledge on the utility of glycated albumin and fructosamine in African patients. The diagnosis and monitoring of DM in African patients may be compromised by associated conditions like sickle cell anaemia, chronic kidney disease and HIV infection. Glycated albumin reflects short term glycaemia and is not affected by many condition...
Source: Indian Journal of Clinical Biochemistry - Category: Biochemistry Source Type: research
by Laura M. Raffield, Jacob C. Ulirsch, Rakhi P. Naik, Samuel Lessard, Robert E. Handsaker, Deepti Jain, Hyun M. Kang, Nathan Pankratz, Paul L. Auer, Erik L. Bao, Joshua D. Smith, Leslie A. Lange, Ethan M. Lange, Yun Li, Timothy A. Thornton, Bessie A. Young, Goncalo R. Abecasis, Cathy C. Laurie, Deborah A. Nickerson, Steven A. McCarroll, Adolfo Correa, James G. Wilson, NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium, Hematology&Hemostasis, Diabetes, and Structural Variation TOPMed Working Groups , Guillaume Lettre, Vijay G. Sankaran, Alex P. Reiner Co-inheritance of α-thalassemia has a significant p...
Source: PLoS Genetics - Category: Genetics & Stem Cells Authors: Source Type: research
American Journal of Hematology,Volume 93, Issue 4, Page E107-E109, April 2018.
Source: American Journal of Hematology - Category: Hematology Source Type: research
CONCLUSION: The SS form of the disease, recurrent vaso-occlusive crisis, male sex and advanced age were the main precipitating factors in the development of renal function disorders. PMID: 29311011 [PubMed - as supplied by publisher]
Source: Nephrologie and Therapeutique - Category: Urology & Nephrology Authors: Tags: Nephrol Ther Source Type: research
Authors: Gladwin MT Abstract Sickle cell disease (SCD) is an autosomal recessive disease in which homozygosity for a single point mutation in the gene encoding the β-globin chain produces hemoglobin S molecules that polymerize within the erythrocyte during deoxygenation; the result is sustained hemolytic anemia and vaso-occlusive events. As patients live to adulthood, the chronic impact of sustained hemolytic anemia and episodic vaso-occlusive episodes leads to progressive end-organ complications. This scenario culminates in the development of 1 or more major cardiovascular complications of SCD for which there...
Source: Hematology ASH Education Program - Category: Hematology Tags: Hematology Am Soc Hematol Educ Program Source Type: research
Suicidal erythrocyte death or eryptosis contributes to or even accounts for anemia in a wide variety of clinical conditions, such as iron deficiency, dehydration, hyperphosphatemia, vitamin D excess, chronic kidney disease (CKD), hemolytic-uremic syndrome, diabetes, hepatic failure, malignancy, arteriitis, sepsis, fever, malaria, sickle-cell disease, beta-thalassemia, Hb-C and G6PD-deficiency, Wilsons disease, as well as advanced age. Moreover, eryptosis is triggered by a myriad of xenobiotics and endogenous substances including cytotoxic drugs and uremic toxins. Eryptosis is characterized by cell membrane scrambling with ...
Source: Cellular Physiology and Biochemistry - Category: Cytology Source Type: research
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Source: International Journal of Cancer - Category: Cancer & Oncology Authors: Tags: Mini Review Source Type: research
Hemolysis is a fundamental feature of sickle cell anemia that contributes to its pathophysiology and phenotypic variability. Decompartmentalized hemoglobin, arginase 1, asymmetric dimethylarginine, and adenine nucleotides are all products of hemolysis that promote vasomotor dysfunction, proliferative vasculopathy, and a multitude of clinical complications of pulmonary and systemic vasculopathy, including pulmonary hypertension, leg ulcers, priapism, chronic kidney disease, and large-artery ischemic stroke. Nitric oxide (NO) is inactivated by cell-free hemoglobin in a dioxygenation reaction that also oxidizes hemoglobin to ...
Source: Journal of Clinical Investigation - Category: Biomedical Science Authors: Source Type: research
The diagnosis of prediabetes and diabetes mellitus is often assigned based on assessment of discrete hemoglobin A1c (HbA1c) levels. Several studies have identified factors that affect HbA1c, including African ancestry, chronic kidney disease, and iron deficiency anemia. Increasing evidence suggests that at a given glucose level, white people have lower HbA1c levels than black people, although the effect of sickle cell trait (SCT) on HbA1c levels is not clearly defined. Approximately 10% of the black population has SCT.
Source: JAMA - Category: Journals (General) Source Type: research
Authors: Dueker ND, Della-Morte D, Rundek T, Sacco RL, Blanton SH Abstract Sickle cell anemia (SCA) is a common hematological disorder among individuals of African descent in the United States; the disorder results in the production of abnormal hemoglobin. It is caused by homozygosity for a genetic mutation in HBB; rs334. While the presence of a single mutation (sickle cell trait, SCT) has long been considered a benign trait, recent research suggests that SCT is associated with renal dysfunction, including a decrease in estimated glomerular filtration rate (eGFR) and increased risk of chronic kidney disease (CKD) i...
Source: Ethnicity and Disease - Category: Global & Universal Tags: Ethn Dis Source Type: research
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