Have dipeptidyl peptidase-4 inhibitors ameliorated the vascular complications of type 2 diabetes in large-scale trials? The potential confounding effect of stem-cell chemokines

Drugs that inhibit dipeptidyl peptidase-4 (DPP-4) are conventionally regarded as incretin-based agents that signal through the glucagon-like peptide-1 (GLP-1) receptor. However, inhibition of DPP-4 also potent...
Source: Cardiovascular Diabetology - Category: Cardiology Authors: Tags: Review Source Type: research

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Publication date: Available online 18 October 2019Source: Molecular and Biochemical ParasitologyAuthor(s): Felicity E. Lumb, Jenny Crowe, James Doonan, Colin J. Suckling, Colin Selman, Margaret M. Harnett, William HarnettAbstractOne of the most rapidly increasing human public health problems is obesity, whose sequelae like type-2 diabetes, represent continuously worsening, life-long conditions. Over the last 15 years, data have begun to emerge from human and more frequently, mouse studies, that support the idea that parasitic worm infection can protect against this condition. We have therefore investigated the potential of...
Source: Molecular and Biochemical Parasitology - Category: Parasitology Source Type: research
Publication date: Available online 18 October 2019Source: Journal of Molecular BiologyAuthor(s): Leticia P. Roma, Jean-Christophe JonasAbstractInsulin-secreting pancreatic β-cells play a critical role in blood glucose homeostasis and the development of type 2 diabetes (T2D) in the context of insulin resistance. Based on data obtained at the whole cell level using poorly specific chemical probes, reactive oxygen species (ROS) like superoxide and hydrogen peroxide have been proposed to contribute to the stimulation of insulin secretion by nutrients (positive role) and to the alterations of cell survival and secretory fu...
Source: Journal of Molecular Biology - Category: Molecular Biology Source Type: research
Publication date: Available online 18 October 2019Source: Life SciencesAuthor(s): Ricardo Beltrame de Oliveira, Valquiria Aparecida Matheus, Leandro Pereira Canuto, Ariane De Sant'ana, Carla Beatriz Collares-BuzatoAbstractAimHigh-fat diet (HFD) intake has been associated with changes in intestinal microbiota composition, increased intestinal permeability, and onset of type 2 diabetes mellitus (T2DM). The aim of this work was twofold: 1) to investigate the structural and functional alterations of the tight junction (TJ)-mediated intestinal epithelial barrier of ileum and colon, that concentrate most of the microbiota, after...
Source: Life Sciences - Category: Biology Source Type: research
Publication date: May 2020Source: Value in Health Regional Issues, Volume 21Author(s): Xiaomeng Yue, Jiuhong Wu, Zhen Ruan, Michael L. Wolden, Lanting Li, Yong LinAbstractBackgroundHypoglycemia is a common acute complication in patients with diabetes and markedly impacts on medical resource use.ObjectivesTo make an initial assessment of the incidence of hypoglycemia and the associated utilization of medical resources and medical costs in insulin-treated patients with diabetes using medical records from 4 tertiary hospitals in China.MethodsA retrospective cohort study was conducted using electronic medical records from 4 te...
Source: Value in Health Regional Issues - Category: International Medicine & Public Health Source Type: research
TYPE 2 diabetes is a chronic condition that requires a complete overhaul of one ’s eating habits to help stave off health risks. When it comes to snacking late at night, what foods should be avoided and which ones could help lower blood sugar levels?
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
CONCLUSIONS The frequency of sternotomy wound infection in patients with type 2 diabetes is comparable between patients treated with traditional dressings and those receiving silver dressings; therefore, to maximize cost savings, providers should consider using standard wound dressings in this patient population.
Source: Advances in Skin and Wound Care - Category: Dermatology Tags: FEATURES: ORIGINAL INVESTIGATION Source Type: research
Publication date: Available online 16 October 2019Source: Journal of Molecular BiologyAuthor(s): Lena Eliasson, Romano RegazziAbstractPancreatic β-cells located within the islets of Langerhans play a central role in metabolic control. The main function of these cells is to produce and secrete insulin in response to a rise in circulating levels of glucose and other nutrients. The release of insufficient insulin to cover the organism needs results in chronic hyperglycemia and diabetes development. β-cells insure a highly specialized task and to efficiently accomplish their function they need to express a specific s...
Source: Journal of Molecular Biology - Category: Molecular Biology Source Type: research
Publication date: Available online 16 October 2019Source: Journal of Molecular BiologyAuthor(s): Maria Lytrivi, Castell Anne-Laure, Vincent Poitout, Miriam CnopAbstractThe deleterious effects of chronically elevated free fatty acid (FFA) levels on glucose homeostasis are referred to as lipotoxicity, and the concurrent exposure to high glucose may cause synergistic glucolipotoxicity. Lipo- and glucolipotoxicity have been studied for over 25 years. Here, we review the current evidence supporting the role of pancreatic β-cell lipo- and glucolipotoxicity in type 2 diabetes, including lipid-based interventions in humans, p...
Source: Journal of Molecular Biology - Category: Molecular Biology Source Type: research
ConclusionsLess than 30% of Americans with diabetes receive diet or exercise counseling in ambulatory visits, and this proportion has not changed significantly in a decade. Future interventions should focus on addressing this gap in counseling.
Source: American Journal of Preventive Medicine - Category: International Medicine & Public Health Source Type: research
Yen Huang Severe periodontitis is a risk factor for poor glycemic control. The appropriate medicaltreatment and plaque control of periodontitis positively affects blood-sugar control in diabetespatients. We aimed to identify the factors associated with glycemic control and examine theperiodontal treatment (PT) experience and oral health-related quality of life (OHQoL) for patientswith poor glycemic control in type 2 diabetes mellitus (T2DM). This multicenter case–control studyrecruited 242 patients with poor glycemic control and 198 patients with good glycemic control. Wecollected patients’ inf...
Source: International Journal of Environmental Research and Public Health - Category: Environmental Health Authors: Tags: Article Source Type: research
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